伴發(fā)認(rèn)知障礙帕金森病的彌散張量成像研究

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1、1生!Q箍!鲞箍2Q翅ChinJClinicians(ElectronicEdition)，October15．2013．Vo1．7．No．2·臨床論著·伴發(fā)認(rèn)知障礙帕金森病的彌散張量成像研究張雷范國光武成華【摘要】目的探討彌散張量成像(DTI)對伴發(fā)認(rèn)知障礙帕金森病的診斷價值。方法對11例帕金森病伴癡呆患者，13例帕金森病伴輕度認(rèn)知障礙患者，12例單純帕金森病患者及10例正常對照組志愿者行DTI掃描，采用人工勾畫感興趣區(qū)(R0I)的方法在DTI參數(shù)圖上測量各ROI(雙側(cè)扣帶束、上縱束、下縱束、鉤束、齒狀核)的各向異性分?jǐn)?shù)(FA)值，采用單因素方差分析方法進(jìn)行統(tǒng)計

2、分析。結(jié)果所有帕金森病組雙側(cè)扣帶束、雙側(cè)上縱束、左側(cè)鉤束及右側(cè)齒狀核的FA值均低于對照組(尸<0．05)；右側(cè)鉤束、左側(cè)齒狀核FA值改變僅在單純帕金森病組、對照組間無統(tǒng)計學(xué)差異；左側(cè)下縱束FA值僅在帕金森病伴癡呆組、對照組間有統(tǒng)計學(xué)差異(P<0．05)，而右側(cè)下縱束FA值改變均無統(tǒng)計學(xué)差異。在各帕金森病組間比較時雙側(cè)扣帶束、右側(cè)上縱束、雙側(cè)鉤束、右側(cè)齒狀核FA值改變均具有統(tǒng)計學(xué)差異，而左側(cè)上縱束FA值改變僅在單純帕金森病組、帕金森病伴癡呆組間具有統(tǒng)計學(xué)差異(P

3、改變可能累及腦白質(zhì)纖維和小腦?！娟P(guān)鍵詞】帕金森病；認(rèn)知障礙；磁共振成像，彌散DifusiontensorimagingstudiesofParkinson’sdiseasewithcognitiveimpairmentZ4ⅣGLei,FANGuo-guang,Cheng-hua．DepartmentofRadiology,theFirstHospitalofChinaMedicalUniversity,Shengyang110001，ChinaCorrespondingauthor：FANGuo-guang,EmaiL"fanguog@vip．sina．eom[A

4、bstract]ObjectiveTostudythevalueofdiffusiontensorimaging(DT1)inthediagnosisofParkinson'sdiseasewithcognitiveimpairment．MethodsDT1wasperformedin11patients、出PDD．13PDpatientswithMCI,12purePDpatientsand10controlsubjects．Regionsofinterest(ROI)weredrawninbilateralcingulum，upperlongitudinal，

5、underlongitudinal，uncinatefasciculusandthedentatenucleusonfractionalanisotropy(FA)map．DiferencesinFAbetweenthethesegroupswerestudiedbyone—factorANOVA．ResultsFAvaluesofbilateralcingulum,bilateralupperlongitudinal，leftuncinatefasciculusandfightdentatenucleusinallPDgroupswerelowerthancon

6、trolgroup<0．05)；FAvaluesofrightuncinatefasciculusandleftdentatenucleushadnosignificantchangesonlyinpurePDgroupandcontrolgroup；FAvaluesofleftunderlongitudinalhadsignificantchangesonlyinPDDandcontrolgroup；FAvaluesoffightunderlongitudinalinallgroupshadnosignificantchanges．FAvaluesofbilat

7、eralcingnlum，fightupperlongitudinal，bilateraluncinatefasciculusandrightdentatenucleushadsignificantchangesinallPDgroupswhentheywerecomparedbetweeneachother；FAvaluesofleftupperlongitudinalhadsignificantchangesonlyinpurePDandPDDgroup；FAvaluesofleftdentatenucleushadnosignificantchangeson

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