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1、用藥物與臨床2012年苤15!塑塑ac墮嬰塑Y壘叢墾壁:,::::!·論著·雙黃燒傷膏對大鼠燒傷、燙傷的治療作用研究朱曉紅,凌磊,王楊,王強(qiáng)[摘要]目的研究雙黃燒傷膏對大鼠實(shí)驗(yàn)性燙傷、燒傷感染的治療作用。方法將大鼠隨機(jī)分為實(shí)驗(yàn)組(雙黃燒傷膏組)、陽性對照組(京萬紅軟膏組)、空白對照組。建立大鼠Ⅱ度燙傷模型、Ⅲ度燒傷感染模型,分別涂布給藥,單籠飼養(yǎng),觀察并記錄創(chuàng)面變化。結(jié)果在大鼠燙傷實(shí)驗(yàn)中,給藥15d后,各組創(chuàng)面結(jié)痂面積明顯變小.實(shí)驗(yàn)組結(jié)痂愈合時(shí)間短,與陽性對照組、空白對照組比較,差異有統(tǒng)計(jì)學(xué)意義(P<0.05、P<0.O1);20d創(chuàng)面面積與陽性對照組相比,差異無統(tǒng)計(jì)學(xué)
2、意義(P>0.05),與空白對照組相比,差異有統(tǒng)計(jì)學(xué)意義(P<0.O1)。在大鼠燒傷感染試驗(yàn)中,給藥9d后,實(shí)驗(yàn)組與陽性對照組相比,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),與陰性對照組相比,差異有統(tǒng)計(jì)學(xué)意義(P<0.01)。結(jié)論雙黃燒傷膏對大鼠實(shí)驗(yàn)性燙傷、燒傷感染具有較好的治療作用。[關(guān)鍵詞]雙黃燒傷膏;燙燒傷;感染;藥效學(xué).ExperimentalstudiesofshuanghuangburnointmenttreatmentforscaldandburnwoundofratmodelZHUXiao.hong,LINGLei,WANGYang,WANGQiang(Base
3、forClinicalPharma-cology,No.202HospitalofPLA,Shenyang110003,China)[Abstract]0bjectiveTostudytheeffectsofshuanghuangbumointmentonscaldandburnedinfectiousrats.MethodsRatswererandomlydividedintotestgroup(shuanghuangbumointment),positivecontrolgroup(jingwan—hongcream)andnotreatmentgrouprespe
4、ctively.Thedrugswereadministeredtopicallyonthesurfaceofscaldedandburnedinfectionplacesrespectivelyafterpartical—thicknessscaldandburninrats.Thechangeofthescaldedandburnedareasandthedecrustationtimewererecorded.ResultsInthepartical—thicknessscaldingtest,thescaldedareasof15dweresmaller,the
5、rewassignificantdifferencebetweentestgroupandpositivecontrolgroup(P<0.05),therewassig—nificantdifferencebetweentestgroupandnotreatmentgroup(P<0.O1);thescaldedareasof20d:therewassignifi—cantdifferencebetweentestgroupandnotreatmentgroup(P<0.01),buttherewasnosignificantdifferencecomparedwit
6、hthepositivecontrolgroup.Inthepartical-thicknessburnninginfectiontest,thescaldedareasof9d,therewassig—nificantdifferencebetweenthetestgroupandthenotreatmentgroup(P<0.O1),buttherewasnosignificantdifferencecomparedwiththepositivecontrolgroup.ConclusionBurnointmenthasagoodanti—inflammatory,
7、antibacterialandanalgesiceffect.Keywords:Shuanghuangburncream;Scaldsandbums;Infection;Pharmacod),namics燒傷為平時(shí)及戰(zhàn)時(shí)常見外傷,隨著高技術(shù)武中國醫(yī)藥工業(yè)公司(批號(hào):09036884);注射用水(5器如燃料空氣炸彈、氣浪彈、新型燃燒武器等的發(fā)mL),沈陽志鷹制藥廠(批號(hào):2011051507);硫化展,燒傷的發(fā)生率較以往戰(zhàn)爭不斷增加。在燒傷鈉(分析純),沈陽市新西試劑廠(批號(hào):05007);膏的治療中,外治療法居多,外用藥物在治療燒傷中狀