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1、-4484-2013年11月中國醫(yī)學(xué)物理學(xué)雜志NOV．，2013第3O卷第6期ChineseJournalofMedicalPhysicsVo130．No．6巨塊肝癌分靶區(qū)與單靶區(qū)計(jì)劃設(shè)計(jì)對比李玉，徐慧軍，張素靜(解放軍第302醫(yī)院腫瘤放射治療中心，北京100039)摘要：目的：為了提高腫瘤的覆蓋率，解決靠近敏感器官的腫瘤邊緣劑量不足的問題，探討對巨塊肝癌進(jìn)行分靶區(qū)治療計(jì)劃設(shè)計(jì)。方法：在治療計(jì)劃設(shè)計(jì)時(shí)把計(jì)劃靶區(qū)(PTv)分成三個(gè)子靶區(qū)，分別為PTV1、PTV2和PTV3。PTV1和PTV3為計(jì)劃設(shè)計(jì)區(qū)，PTV2是
2、PTv1與PTV3之間的間隔區(qū)。選取2例巨塊肝癌病例，采用相同的處方劑量和敏感器官限量，分別采用單靶區(qū)和分靶區(qū)進(jìn)行計(jì)劃設(shè)計(jì)，然后對這兩種方法設(shè)計(jì)出來的結(jié)果進(jìn)行對比和評(píng)估。結(jié)果：病例1，單靶區(qū)和分靶區(qū)計(jì)劃設(shè)計(jì)下的腫瘤覆蓋率分別為66．51％和99．00％。病例2，單靶區(qū)和分靶區(qū)計(jì)劃設(shè)計(jì)的腫瘤覆蓋率分別為56．85％和92．00％。結(jié)論：病例1和病例2通過分靶區(qū)計(jì)劃設(shè)計(jì)，腫瘤覆蓋率分別提高了32．49％和35．15％。分靶區(qū)計(jì)劃設(shè)計(jì)大大提高了腫瘤的覆蓋率，但增加了患者的治療次數(shù)，延長了治療時(shí)間。關(guān)鍵詞：巨塊肝癌：分靶
3、區(qū)：計(jì)劃設(shè)計(jì)DOI編碼：doi：10．39698．issn．1005-202X．2013．06．004中文分類號(hào)：R811．1文獻(xiàn)標(biāo)識(shí)碼：A文章編號(hào)：1005—202一X(2013)06—4484—03DesigningTreatmentPlansUsingDividedTargetsforStereotacticBodyRadiotherapyofMassiveLiverCancerTumorsLiYu，XuHuidun，ZhangSu-jing(OncologyRadiotherapyCenterof302M
4、ilitaryHospital，Be~ing100039，China)Abstract：Objective：InordertoimprovecoveragetothesetumorsandresolvetheproblemofdoseshortagetothetUlYlOredgesthatarenearorgansatrisk(OARs)，wedesignedtreatmentplansusingdividedtargetsforstereotacticradiotherapyofmassivelivercan
5、certumors．Methods：Wedividedtheplanningtargetvolume(PTV)intothreesub-targetswhendesigningtreatmentplans：PTV1，PTV2andPTV3．ThePTV1andPTV3weretheregionsforwhichtreatmentplansweredesigned，andthePTV2wasthespacerregionbetweenPTV1andPTV3．Weselectedtwocasesofmassiveli
6、vercancerandadoptedthesameprescribeddoseanddosethresholdforOARSforbothcases．Foreachofthesetwocases，wedesignedone—planforasingletargetandasecondplanfordividedtargets．Wethencomparedandevaluatedtheresultsofthesetwoplans．Results：ForCase1，thetumorcoverageratesinsi
7、ngle—targetplanandindivided—targetsplanwere66．51％and99．00％，respectively．ForCase2，thecoverageratesinsingle—targetplanandindivided—targetsplanwere56．85％and92．00％，respectively．Conclusions：Becauseofthedivided-targetsplan，thetumorcoverageofCase1andCase2improved32．
8、49％and35．15％，respectively．Themethodofdivided—targetsplangreatlyimprovedtUlTlOrcoverage．However，italsoincreasedtreatmenttimeforpatients．Keywords：massivelivercancertumor；dividedtargetsregio
