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《S-腺苷蛋氨酸對梗阻性黃疸患者術(shù)后肝功能及營養(yǎng)狀況影響的臨床研究-論文.pdf》由會員上傳分享,免費在線閱讀,更多相關(guān)內(nèi)容在應用文檔-天天文庫。
1、現(xiàn)代生物醫(yī)學進展www.shengwuyixue.comProgressinModernBiome~cmeVoL14NO.1JAN.2014·147·DOI:10.13241~.cnki.pmb.2014.01.036s.腺苷蛋氨酸對梗阻性黃疸患者術(shù)后肝功能及營養(yǎng)狀況影響的臨床研究齊敦峰李歡送姜新春△孟凡軍張昕輝劉養(yǎng)歲(徐州中心醫(yī)院肝膽胰外科江蘇徐州221009)摘要目的:探討s一腺苷蛋氨酸對梗阻性黃疸患者術(shù)后肝功能及營養(yǎng)狀況的影響。方法:選擇2010年8月至2012年7月我院肝膽病區(qū)收治的90例梗阻性黃疸患者為研究對象,隨機分為s一腺苷蛋氨酸治療組(48例)和對照組
2、(42例),比較和分析靜脈滴注s一腺苷蛋氨酸對梗阻性黃疸患者術(shù)后第5d、10d肝功能及營養(yǎng)指標的影響。結(jié)果:術(shù)后5d、10d,兩組患者血總膽紅素、直接膽紅素、谷丙轉(zhuǎn)氨酶、^v.谷氨酰轉(zhuǎn)肽酶、堿性磷酸酶水平較術(shù)前l(fā)d顯著降低,且組內(nèi)比較差異有統(tǒng)計學意義(P<0.05),治療組以上指標的下降程度較對照組更明顯,差異有統(tǒng)計學意義(P<0.05)。術(shù)后第10d,兩組患者的血白蛋白、前白蛋白、轉(zhuǎn)鐵蛋白水平較術(shù)后第5d顯著改善(P<0.05);術(shù)后第5、10d,兩組組間血白蛋白、前白蛋白、轉(zhuǎn)鐵蛋白水平比較差異有統(tǒng)計學意義(P<0.05)。結(jié)論:梗阻性黃疸患者術(shù)后應用腺苷蛋氨酸能促
3、進黃疸消退,加快膽紅素的排泄和肝功能的恢復,有利于患者營養(yǎng)狀況的改善。關(guān)鍵詞:梗阻性黃疸;s一腺苷蛋氨酸;肝功能;營養(yǎng);術(shù)后中圖分類號:R657.43文獻標識碼:A文章編號:1673—6273(2014)O1—147—03ObservationontheEfiectofS.a(chǎn)denosyl—L—methionineonPost—operativeLiveFunctionandNutritionalStatusinPatientswithObstructiveJaundiceQIDun-feng,LIHuan—song,JIANGXin—chun△.MENGFan-ju
4、n,ZHANGXin-huiL1UYang-sui(XuzhouCentralHospitalofHepatobiliaryspleensurgical,Xuzhou,Jiangsu,221009,ChinaJABSTRACTObjective:TostudytheefectsofS-adenosylmethionineonpost-operativeliverfunctionandnutritionalstatusinpatientswithobstructivejaundice.Methods:90casesofobstructivejaundiceadmitte
5、dfromAugust2010toJuly2012wereselectedanddividedintotheexperimentalgroup(withS-adenosylmethioninetreatment)andcontrolgrouprandomly.TheefectofintravenousinfusionwithS-adenosylmethionineontheliverfimctionandnutritionindicatorson5and10daysafteroperationinpatientswithobstructivejaundicewerec
6、omparedandanalyzed.Results:5and10dayspostoperation,theTBIL,DBIL,ALT,一GTandALPlevelsweresignificantlyreducedcomparedwiththosepre—operation(P<0.05),whichwereobviouslylowerintheexperimentalgroupcomparedwiththecontrolgroup(P<0.05).10daysafterpostoperation,thelevelsofAlb,PA,TFoftwogroupsboth
7、significantlyimprovedcomparedwiththoseafter5dayspostoperation(P<0.05);whichweresignificantlydiferentbetweenthetwogroups5and10daysafterpostoperation(P<0.05).Conclusion:S-adenosylmethioninecouldpromotetheexcretionofserumbilirubin,jaundicesubsidise,recoveryofliverfunctionaswellast