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1、安徽醫(yī)藥AnhuiMedicalandPharmaceuticalJournal2014Feb;18(2)·275·原發(fā)性肝癌發(fā)病危險因素的病例對照分析鐘文洲,陳正義,王齊全(海南省??谑腥嗣襻t(yī)院消化內(nèi)科,海南???70208)摘要:目的探討原發(fā)性肝癌的危險因素和肝癌病發(fā)的相關(guān)性,為其預防提供參考。方法選擇2009年9月至2013年1月期間在該院治療的原發(fā)性肝癌患者256例作為觀察組,選擇同時期健康體檢者358例作為對照組。調(diào)查兩組HBV感染、飲酒、飲茶、食用剩飯菜、食用腌制食品、吸煙、家族肝癌史、慢性肝病史、文化程度、生活質(zhì)量等情況,并進行l(wèi)ogistic
2、回歸分析,應(yīng)用比值比(OR)和95%可信區(qū)間(95%cI)進行評估。結(jié)果觀察組和對照組在HBV感染、飲酒、飲茶、食用剩飯菜、食用腌制食品、吸煙、家族肝癌史、慢性肝病史、文化程度、生活質(zhì)量等方面均存在顯著差異,經(jīng)多因素非條件Logistic回歸分析,HBV感染、飲酒、飲茶、食用剩飯菜、家族肝癌史、慢性肝病史、生活質(zhì)量其OR值分別為13.524、4.856、0.080、3.806、24.691、19.815和0.095,95%C1分另1為6.952~18.625、3.784~7.367、0.059—0.605、3.018~8.224、10.890~35.265、
3、8.754~29.543和0.275—0.569。結(jié)論HBV感染、飲酒、家族肝癌史、慢性肝病史、食用剩飯菜可能是原發(fā)性肝癌的主要危險因素;吸煙和吃食用腌制食品可能是其次要危險因素;飲茶和生活質(zhì)量則可能是其重要保護因素;文化程度可能是其次要保護因素。關(guān)健詞:原發(fā)性肝癌;危險因素;logistic回歸分析;HBV感染doi:10.3969/j.issn.1009—6469.2014.02.019Primarylivercancer:case—controlanalysisofdiseaseriskfactorsZHONGWen—zhou,CHENZheng—yi
4、,WANGQi—quan(DepartmentofGastroenterology,ThePeople’sHospitalofHaikouCity,Hainan570208,China)Abstract:0bjectiveToexploretheriskfactorsofprimarylivercancerandliverdisease,toprovidereferenceforitsprevention.Meth-odsFromSeptember2009toJanuary2013,256patientswithprimarylivercancerweres
5、electedasobservationgroupinourhospital,358casesofhealthyphysicalexaminationinourhospitalwereselectedascontrolgroup.TwogroupsweresurveyedintheaspectofHBVinfection,alcohol,drinkingtea,eatingleftovers,pickledfoods,smoking,familyhistoryoflivercancer,thedegreeofchronicliverdiseasehistor
6、y,culture,qualityoflife,etc.Thentwogroupswereinthelogisticregressionanalysis,andtheywereappliedoddsratio(OR)and95%confidenceintervals(95%CI)forevaluation.ResultsBetweenobservationgroupandcontrolgroupinHBVinfection,alcohol,drinkingtea,eatingleftovers,pickledfoods,smoking,familyhisto
7、ryoflivercancer,thedegreeofchronicliverdiseasehistory,culture,qualityoflifeaspectsthereweresignificantdifferences.Themulti—factorunconditionedLogisticregressionanalysisshowedthatORval·uesofHBVinfection,alcohol,drinkingtea,eatingleftovers,familyhistoryoflivercancer,historyofchronicl
8、iverdisease,andqualityofli