簡(jiǎn)易胰島素釋放試驗(yàn)對(duì)評(píng)價(jià)胰島B細(xì)胞功能的意義.pdf

《簡(jiǎn)易胰島素釋放試驗(yàn)對(duì)評(píng)價(jià)胰島B細(xì)胞功能的意義.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。

1、第35卷第6期西安交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)Vo1．35No．62014年11月JournalofXi’anJiaotongUniversity(MedicalSciences)Nov．2O14◇經(jīng)驗(yàn)交流◇簡(jiǎn)易胰島素釋放試驗(yàn)對(duì)評(píng)價(jià)胰島B細(xì)胞功能的意義劉付貞，黃曉君，黃貴心，黎堅(jiān)健，陳燕霞(廣東醫(yī)學(xué)院附屬醫(yī)院內(nèi)分泌科，廣東湛江524001)摘要：目的探索簡(jiǎn)易胰島素釋放試驗(yàn)(insulinreleasetest，IRT)對(duì)評(píng)價(jià)2型糖尿病患者胰島B細(xì)胞功能的價(jià)值。方法對(duì)廣東醫(yī)學(xué)院附屬醫(yī)院2003～2013年門診以及住院的1631例2

2、型糖尿病患者和168例健康人(正常糖耐量組，即NGT組)口服75g無(wú)水葡萄糖粉，行簡(jiǎn)易IRT和相應(yīng)時(shí)點(diǎn)的血糖測(cè)定，按測(cè)定結(jié)果將糖尿病患者再分為空腹胰島素低值組(A組)、空腹胰島素正常組(B組)、空腹胰島素高值組(C組)，將A、B、c各組的結(jié)果分別與NGT組進(jìn)行比較。結(jié)果NGT組中，血清胰島素的峰值出現(xiàn)在餐后1h，峰值為空腹血清胰島素值的5倍以上，餐后2h時(shí)血清胰島素明顯降低。A組各時(shí)點(diǎn)的血清胰島素值均低于NGT組，在餐后2h時(shí)出現(xiàn)低峰值，各時(shí)點(diǎn)的血清胰島素值與NGT組相比差異均有統(tǒng)計(jì)學(xué)意義(P

3、h與NGT組無(wú)差異，峰值出現(xiàn)在餐后2h，餐后2h血清胰島素值與NGT組相比差異有統(tǒng)計(jì)學(xué)意義(P

4、406027SignificanceofeasyinsulinreleasetesttoevaluatethefeasibilityofisletfunctionLIUFu—zhen，HUANGXiao—jun，HUANGGui—xin，LIJian—jian，CHENYan—xia(DepartmentofEndocrino1ogy，theAffiliatedHospitalofGuangdongMedicalCollege，Zhanjiang524001，China)ABSTRACT：ObjectiveToobserv

5、ewhethereasyinsulinreleasetest(IRT)isofclinicalsignificanceinevaluatingisletBcellfunctionofpatientswithtypeIIdiabetesmellitus(DM)．MethodsWegave1631DMpatientswhocametoourhospitalbetween2003to2013and168healthypeople75ganhydrousglucosepowderorally，andtestedtheirblood

6、glucoseandinsulinlevelbeforeandaftertakingglucoserespectively．Theyweredividedinto4groupsbasedonthetestresults：normalglucosetolerancegroup(NGT)，lowfastinginsulingroup(A)，normalfastinginsulingroup(B)，andhighfastinginsulingroup(C)．TheresultsofA，B，Cgroupswerecompareds

7、eparatelywiththoseofNGTgroup．ResultsInNGTgroup，theinsulinlevelreachedthepeakat1haftermeal，andthepeakvaluewas5timeshigherthanthatoffasting．Itdecreasedobviouslyat2haftermea1．IngroupA，seruminsulinvaluesatalltimepointswerelowerthanthoseinNGTgroup，andtherewasalowpeakat

8、2haftermea1．SeruminsulinvaluesatalltimepointsdifferedsignificantlyfromthoseinNGTgroup(P<0．O5)．IngroupB，fastingandpostprandial1hourinsulinlevelshadnodiff