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1、CN43—1262/R中國動脈硬化雜志2014年第22卷第6期[文章編號]1007-3949(2014)22-06-0607-06·臨床研究·血清胱抑素C與頸動脈狹窄程度的相關(guān)性研究賈建普,王麗軒,張樂國,姬春雪。張俊玲(滄州市中心醫(yī)院神經(jīng)內(nèi)科,河北省滄州市061001)[關(guān)鍵詞]胱抑素C;頸動脈狹窄;免疫比濁法[摘要]目的探討短暫性腦缺血發(fā)作或小卒中患者血清胱抑素c(CysC)與頸動脈狹窄程度的關(guān)系。方法選擇完成頭頸部CT血管造影(CTA)檢查的短暫性腦缺血發(fā)作或小卒中患者共計229例,分為頸動脈狹窄組127例(包括輕度狹窄組57例、中度狹窄組34例、重度狹窄組24例、閉塞
2、組12例4個亞組)和非狹窄組102例。應(yīng)用免疫比濁法測定血清CysC水平,分析血清CysC水平與頸動脈狹窄程度之間的相互關(guān)系。結(jié)果頸動脈狹窄組血清CysC、同型半胱氨酸高于非狹窄組(P<0.01)。Spearman相關(guān)分析發(fā)現(xiàn)頸動脈狹窄與年齡、CysC、同型半胱氨酸、尿酸、高血壓、糖尿病呈正相關(guān)(P<0.05),Logistic回歸分析顯示血清CysC并非頸動脈狹窄的獨(dú)立危險因素,而年齡、高血壓、糖尿病為頸動脈狹窄的獨(dú)立危險因素。各亞組間分析發(fā)現(xiàn),重度狹窄組CysC水平較非狹窄組顯著升高(P<0.05);重度狹窄組CysC水平較輕度狹窄組、中度狹窄組升高,差異有統(tǒng)計學(xué)意義(P
3、<0.O1,P<0.05)。Logistic回歸分析發(fā)現(xiàn)CysC、甘油三酯、高血壓為頸動脈重度狹窄的獨(dú)立危險因素(P<0.05)。結(jié)論血清CysC水平與頸動脈重度狹窄相關(guān),為頸動脈重度狹窄的獨(dú)立危險因素。[中圖分類號]R543.4[文獻(xiàn)標(biāo)識碼]ACorrelationBetweenSerumCystatinCandtheDegreeofCarotidStenosisJIAJianPu,WANGLi-Xuan,ZHANGLe—Guo,JIChun—Xue,andZHANGJun—Ling(DepartmentofNeurology,CangzhouCentralHospital
4、,Cangzhou,Hebei061001,China)[KEYWORDS]CystatinC;CarotidStenosis;ImmunoturbidimetficAssay[ABSTRACT]AimThestudywastoinvestigatethecorrelationbetweensenlmcystatinC(CysC)andthedegreeofcarotidstenosisinpatientswithtransientischemiaattackorminorstroke.MethodsAtotalof229patientswithtransientischem
5、icattack(TIA)orminorstrokewerecollected,andeachofthemreceivedheadandneckcomputedtomo-graphyangiography(CTA)inspection.Allofthepatientsweredividedintotwogroups:groupwithcarotidstenosisandgroupwithoutcarotidstenosis.Thegroupwithcarotidstenosisincluded127subjectsofpatients,whichisdividedinto4s
6、ubgroups:44subjectsofmildcarotidstenosissubgroup,34subjectsofmoderatecarotidstenosissubgroup,24subjectsofseverecarotidstenosissubgroup,12subjectsofoclussionsubgroup;Another102patientswithoutcarotidstenosiswerese-lectedasthecontrolgroup.ThelevelsofserumCysCweredetectedbyimmunoturbidimetricas
7、say,andthecorrelationbetweenserumCysCandthedegreeofcarotidstenosiswasanalyzed.ResultsSerumCysClevelandhomocysteinelevelwerehigherincarotidstenosisgroupthaninwithoutcarotidstnosisgroup(P<0.O1).Onspearmancorelationa—nalysis,carotidstenosiswascorelatedposit