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1、0l3年9月第7卷第17期ChinJC·臨床論著·慢性丙型肝炎患者自身抗體檢測的臨床意義龔希平周鎮(zhèn)先黃菁黃玲【摘要】目的探討慢性丙型肝炎患者自身抗體檢測的臨床意義。方法應(yīng)用免疫熒光法(I)檢測230例慢性丙型肝炎患者血清中自身抗體,并研究自身抗體與HCVRNA、肝硬化發(fā)生率、年齡、性別以及和的關(guān)系。結(jié)果230例慢性丙型肝炎患者中有95例至少有1項自身抗體陽性,總陽性率為41.5%,明顯高于健康對照組2.5%,兩組比較P<0.01,差異有統(tǒng)計學意義。HCVRNA陽性組與HCVRNA陰性組自身抗體的檢出率差異顯著(P<0.05)。
2、自身抗體陽性組中丙型肝炎肝硬化發(fā)生率(65/95,68.4%)明顯高于自身抗體陰性組(46/125,36.8%)。而且年齡t>40歲以上的患者發(fā)生肝硬化率更高,兩組間比較,P<0.05,差異有統(tǒng)計學意義。結(jié)論慢性丙型肝炎患者中較為普遍存在自身免疫現(xiàn)象,且自身抗體的檢出率與患者的年齡和肝硬化發(fā)生率明顯相關(guān),在丙型肝炎的常規(guī)診療中應(yīng)加強檢測自身抗體,對于慢性丙型肝炎患者的治療具有較強的指導意義。【關(guān)鍵詞】肝炎,丙型,慢性;肝炎病毒屬;自身抗體;肝硬化Cfinicalsignificanceofauto—antibodiesdete
3、ctionandmeasurementforpatientswithchronichepatitisCGONGXi-ping,ZHOUZhen-xian,HUANGJing,HUANGLing.Clinicallaboratory,NanjingSecondHospital,Nanjing210003,ChinaCorrespondingauthor:ZHOUZhen-xian,Email:zzx0417@126.com[Abstract]0bjectiveTostudytheclinicalsignificanceofant
4、ibodydetectionforpatientswithchronichepatitisC.MethodsFor230casesofchronichepatitisCpatients,detectserumauto-antibodiesusingindirectimmunofluoresceuce(HF)method,andco珊paretheresults、)l,iththeHCVRN&cirrhosisincidence,age,gender,andAI.ResultsOutofthe230casesofchronich
5、epatitisCpatients.95casesshowedat1eastoneautoantibodypositive,thetotalpositiveratewas41.5%,significantlyhigherthanthehealthycontrolgroup(2.5%,P6、up.HepatitisCcirrhosisincidenceinautoantibody-positivegroup(65/95,68.4%)wassignificantlyhigherthanthatinautoantibody-negativepatients(46/148,36.8%)(P40yearsoldwassignificantlyhigherinautoantibody-positivegroupthaninautoantibody-negativ
7、egroup(尸<0.05).ConclusionsAutoimmunephenomenaishighlyprevalentinpatientsmchronichepatitisC,thedetectionofauto—antibodiesissignificantlyassociatedwiththepatient'sageandcirrhosisincidence.Thedetectionandmeas~ememofauto—antibodiesandtheirtiterintheconventionaltreatment
8、holdsimportantguidingmeaningforthediagnosisandtremmemofchronichepatitisCpatients.[Keywords]HepatitisC,chronic;Hepacivirus;Autoantibodies;L