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1、AsystematicreviewoftheincidenceofschizophreniaSchizophrenia-themostcommonformofpsychosis–ischaracterisedbydisordersofcognition(egparanoia),affect(mood),communication(thoughtdisorder)andperception(eghallucinations)–leadingtoalossofcontactwithrealityalongwithvariousformsofimpairedbehavior.Bec
2、auseschizophrenia(a)hasanearlyonsetand(b)hasarelapsingorchroniccourse,itisasignificantpublichealthproblem.Itranksinthetop10leadingcausesofdisability,withaburdenofdiseasecomparabletocancerandgreaterthanheartdisease.Previouslytheincidenceofschizophreniahasbeenthoughttoberelativelyuniformacros
3、stimeandplace.TheidentificationofvariationsintheincidenceofschizophreniaisimportantinunravellingthecausesofthedisorderAimsTosystematicallyreviewstudiesoftheincidenceofschizophreniaToexaminevariationintime,placeandpersonbyexaminingthedistributionoftheseratesToexplorealimitednumberofapriorihy
4、pothesesMethods:systematicreviewElectronicdatasearchMedline,PsychoInfo,Embase,LILAC1965-2001inclusive(schizo*ORpsycho*)ANDincidenceORprevalence)alsoReviewarticlebibliographyWrotetoauthorsScreenabstractandreviewedpaperstocullirrelevantcitationsRateitemsanddiscretedataNon-overlappingSexMale,F
5、emaleOverlappingAgeegallagesorage15-54DiagnosisegCategoS+orCategoSPO+clinicalDiagnosticcategoriesegDSMIVSchizophreniaorSchizophrenia+DelusionaldisorderSiteoverlapegDenmarkorCopenhagenEpochoverlapeg1990-92or1989-91Dataanalysis: examplecumulativedistributionRateper100,000ResultsElectronicsear
6、ch=834potentialpapersManualchecking=249potentialpapersLettersfrom52authors,whoprovidedanadditional41referencesOfpotentiallyrelevantpapers,74%wereidentifiedfromelectronicsourcesResults(2)Ratesbasedon176,056potentiallyoverlappingincidentcasesAfterreview158wereincludedfrom32countriesTypesofstu
7、diesCorestudies=100Migrantstudies=24Cohortstudies=23Otherspecialgroups=14CoreIncidenceStudiesSexdifferencesMale:femalerateratioMigrantstatusUrban-ruraldifferencesCohortstudiesAustralia(n=2)Denmark(n=3)Finland(n=5)Israel(n=2)Italy(n=1)Sweden(n=2)TheNether
