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1、MagneticResonanceImaging-Motherisk磁共振成像MotheriskWhatarewetryingtodo?NeuralActivityInResponsetotaskWhereDetectionHowMuchQuantifyWhatdowemeasurewithfMRI?BrainActivityMetabolismBloodFlowO2O2WhatdowemeasurewithfMRI?BrainActivityMetabolismBloodFlowO2O2dHbdHbT2*T2*MRSigna
2、lMRSignalfMRIDataAcquisition HemodynamicResponseFunctionfMRIDataAcquisition BlockDesignfMRIDataAcquisition BlockDesignfMRIBackgroundPhysiologicaleffectsrelatingtochangesinneuronalactivitycausechangesintheMRsignalintensityByimagingavolumeofthebrainorspinalcordrepeate
3、dlyduringalternated“rest”and“task”periods,wecandetectwherethesignalintensitychangedinrelationtotheactivityObjectives:TodetermineFASDchild/adultbrainfunctioninareasofattention,spatialmemoryandworkingmemoryDevelopMRIbasedtechniquestoaiddiagnosisofFASDTodetermineifther
4、earedifferentregionsoffMRIactivityinsubjectswithFASDthancontrolsusingaworkingmemorytaskMethodsSubjects:ChildControln=15ChildFASDn=14AdultControln=10AdultFASDn=10fMRI1.5TGESignaLXMRIsystemGradient-EchoEchoPlanarImaging(EPI)3activationstatesalternatedwith4reststates(N
5、R=56)N-BackTasks(n=0)Simple(2143)(n=1)One-back(NR214)(n=2)Two-back(NRNR21)(n=1)Blank(NR2NR4)N-BackTasksMethods4fMRItasks:SaccadiceyemovementFingermovementWorkingmemory(spatial,object)ProcedurallearningAttentionHUMANBRAIN:PREFRONTALCORTEXA.SpatialworkingmemoryB.Spati
6、alworkingmemory,performanceofself-orderedtasksC.Spatial,objectandverbalworkingmemory,self-orderedtasks,analyticreasoningD.Objectworkingmemory,analyticreasoningScientificAmerican,August1997LobesoftheCerebralCortexPrefrontalcortex(DLPFC)workingmemoryAnteriorcingulatea
7、ttention,responseselectionParietallobediscrimination,memory,spatialperceptionInsulaVisceralfunction,integratesautonomicinfoConnectionstotemporal&parietallobeResponseinhibition/selectionExecutivefunctionBrainRegionsDataAnalysis?50%correctresponsesonfMRItasksChildren(
8、FASD:Control):Blank:9:141-Back:7:13Adults(FASD:Control):Blank:10:101-Back:6:9SPM99(computerprogram)Imagescorrectedformotion,normalisedtoaa
