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1、百白破疫苗接種不良反應(yīng)原因分析及預(yù)防對(duì)策謝亞利李漢華李賀蘭肖瑞[摘要]目的：分析百白破疫苗預(yù)防接種不良反應(yīng)的原因和預(yù)防對(duì)策。方法：對(duì)接種吸附百白破疫苗出現(xiàn)不良反應(yīng)的病例進(jìn)行回顧性分析總結(jié)。結(jié)果：18~24月齡加強(qiáng)免疫組兒童不良反應(yīng)發(fā)生率（含局部反應(yīng)發(fā)生率、全身反應(yīng)發(fā)生率）高于3~6月齡基礎(chǔ)免疫組兒童（P＜0.01），夏秋季不良反應(yīng)發(fā)生率高于冬春季（P＜0.01），吸附全細(xì)胞百白破聯(lián)合疫苗不良反應(yīng)發(fā)生率高于吸附無細(xì)胞百白破聯(lián)合疫苗（P＜0.01）。結(jié)論：接種吸附百白破疫苗時(shí)要注意充分搖勻藥液，選擇正確的接種部位和接種途徑，嚴(yán)格消毒接種部位，并做好接種前后的衛(wèi)生保健宣教工
2、作；遇高溫天氣適當(dāng)推遲接種；推薦使用吸附無細(xì)胞百白破聯(lián)合疫苗。[關(guān)鍵詞]預(yù)防接種；不良反應(yīng)；吸附全細(xì)胞百白破聯(lián)合疫苗；吸附無細(xì)胞百白破聯(lián)合疫苗。Diphtheria-Pertusis-Tetanusvaccinecausesadversereactionsandpreventivemeasures.XIEYa-li,LIHan-hua,LIHuo-lan,etal.(DongkenghospitalofDongguancity,Dongguan523451,Guangdong,China)Abstract：ObjectiveAnalysisofDiphtheria-P
3、ertusis-Tetanusvaccine-preventablecauseofadversereactionstovaccinationandpreventivemeasures.MethodsAdsorptionofDiphtheria-Pertusis-Tetanusvaccinationvaccineadversereactioncaseswereretrospectivelyanalyzedandsummarized.Result18~24-month-oldchildrentostrengthentheimmunegrouptheincidenceofa
4、dversereactions(includingtheincidenceoflocalreactions,theincidenceofsystemicreaction)washigherthan3to6-month-oldchildrenbasedonimmunohistochemistry(P＜0.01),summerandautumnishigherthantheincidenceofadversereactionswinterandspring(P＜0.01),Adsorptionofwhole-cellDiphtheria-Pertusis-Tetanusv
5、accinetheincidenceofadversereactionshigherthantheadsorptionofacellularDiphtheria-Pertusis-Tetanusvaccine(P＜0.01).ConclusionDiphtheria-Pertusis-Tetanuvaccineadsorbedvaccineshakentotheattentionofthefullsolution,choosethecorrectwayofimmunizationandvaccinationsite,strictdisinfectionofinject
6、ionsite,anddoagoodjobbeforeandaftervaccinationofhealthcareandeducation;caseofhightemperaturesappropriatetodefervaccination;recommendtheuseofadsorptionacellularDiphtheria-Pertusis-Tetanuvaccine.KeyWordsVaccination;Adversereactions;Adsorbedwhole-cellDiphtheria-Pertusis-Tetanusvaccine;Adso
7、rptionacellularDiphtheria-Pertusis-Tetanusvaccine.吸附百白破聯(lián)合疫苗是由全細(xì)胞或無細(xì)胞百日咳菌苗原液、精制白喉類毒素及精制破傷風(fēng)類毒素用氫氧化鋁吸附制成的混合疫苗，用于預(yù)防百日咳、白喉和______________________________________________________作者單位：東莞市東坑醫(yī)院，廣東，東莞，523451作者簡(jiǎn)介：謝亞利（1971-），男，本科，公衛(wèi)主管醫(yī)師，疾病預(yù)防控制5破傷風(fēng)3種疾病，是我國現(xiàn)行的計(jì)劃免疫程序規(guī)定的針次最多、使用最廣泛的疫苗，同時(shí)也有很多不良反
