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《hmgb1在肝癌發(fā)生發(fā)展中的初步功能研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、碩士學(xué)位論文PreliminaryfunctionalstudiesofHMGBlinthedevelopmentofhepatocellularCarClnomaGraduatecandidatestudent：XiaoJian—BiaoSupervisor：Prof．ChenLong—HuaBackgroundand0bjection：ABSTRACTPrimaryhepatocellularcarcinoma(HCC)isoneofthemostformsofmalignancytodayIts
2、incidenceisthesixthanditsmortalityisthethirdintheworld，whicheveryyearabout62．6millionpeaplesufferit．whodiedoflivercancerabout344000peopleayearinChina，accountingfor55％oflivercancerdeathsintheworld。Relativetothehi}ghmortalityrate，earlylivercancerfoundthat
3、ratioisverylow．Inrecentyears，althoughthetreatmentsforlivercancerupdate(includingsurgicalresection，livertransplantation(olt)，radiationtherapy，interventionaltherapyandminimallyinvasiveablation，etc．)，butnoobviouslyincreasetheoverallefficacyofthetreatmentof
4、livercancer，andrelapseandmetastasisarestillthemainfactorsinfluencingprognosisoflivercancer．Therefore，tostrengthentheresearchofinvasionandmetastasisoflivercancermolecularmechanisms，miningmeaningfultransferofmolecularmarkersoflivercancer，searchingfornewco
5、ntroltargets，iscurrentlyoneofthehotspotoflivercancer．HMGB1belongstoHMG(highmobilitygroup，HMG)ofthemembersofthefamily,inthe1970Sfoundincalfthymus，isakindofabundantnucleoprotein，ABSTRACTmolecularmass，about30kd，existinalleukaryotes．HMGB1geneswerelocatedonc
6、hromosome13q12，containsfourfiveexonsandintrons，codingproteincontaining215aminoacids．HMGB1ishighlyconservative，humanandrodentwithgreaterthan99％aminoacidsequencehomology,exactlythesameasthatofaminoacidsequenceofratsandmiceHMGB1isdifferentbecauseoftheircel
7、lularlocalizationandplaydifferentfunctionsandbiologicaleffect．Currentstudiessuggestthatinadditiontoasa”lateinflammatorymediatorsstartinflammation，secretedtheextracellularHMGB1mayalsoiscloselyrelatedtotheevolutionoftumorandmetastasis【8，9】。Inactivecellspr
8、oliferationanddifferentiationofcells，geneexpressionofHMGB1hadmildincreases，whileinbreastcancer，melanoma，gastrointestinalstromaltumorcelltumors，andpancreaticcancertissues，theexpressionofHMGB1levelsaresignificantlyhigherthanitscorr
