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1、Brain,Behavior,andImmunityxxx(2011)xxx–xxxContentslistsavailableatSciVerseScienceDirectBrain,Behavior,andImmunityjournalhomepage:www.elsevier.com/locate/ybrbiShortCommunicationImpactofbreastcancerrecurrenceandcancer-speci?cstressonspousehealthandimmunefunctiona,1b,?bbSharlaWells
2、-DiGregorio,KristenM.Carpenter,CarolineS.Dorfman,Hae-ChungYang,cdLauraE.Simonelli,WilliamE.CarsonIIIaDepartmentofPsychiatry,CenterforPalliativeCare,TheOhioStateUniversity,USAbDepartmentofPsychology,TheOhioStateUniversity,USAcHelenF.GrahamCancerCenter,ChristianaCareHealthSystem,U
3、SAdDepartmentofSurgery,CollegeofMedicineandComprehensiveCancerCenter,TheOhioStateUniversity,USAarticleinfoabstractArticlehistory:Spousesofcancerpatientsareat-riskforpoorpsychologicalandphysicalhealthastheycopewiththeReceived18March2011complexnatureofthediseaseandfearsoflosingthe
4、irpartner.Moreover,spousesoftenserveaspatients’Receivedinrevisedform15July2011primaryinformalcaregivers,agroupthatevidencespooroutcomesacrossavarietyofdomains.Thepres-Accepted17July2011entstudyexaminestherelativecontributionsofcancerrecurrence–acancer-speci?cstressfulevent–Avail
5、ableonlinexxxxandthesubjectiveexperienceofcancer-speci?cstress(IES)inasampleofmalespousesofbreastcancersurvivors.WehypothesizedthatstresswouldcontributetopoorerphysicalhealthandcompromisedKeywords:immunefunction.Spouses(recurrence;n=16)ofpatientswhowerecopingwiththeir?rstrecurre
6、nceCancerrecurrencewerematchedtospousesofpatientswithnoevidenceofdisease(disease-free;n=16).Self-reportedStressImmunefunctionphysicalhealth(physicalsymptomsandfatigue)andimmunefunction[T-cellblastogenicresponsetoSpousesthemitogensConcanavalinA(ConA)andphytohemagglutanin(PHA)andT
7、3monoclonalantibody(T3BreastcancerMab)]wereincludedasoutcomes.Resultsindicatedthatpatientrecurrencestatuswasnotasigni?cantuniquepredictorofphysicalhealthorimmunefunction;rather,amongallspouses,cancer-speci?cstresssymptomswereassociatedwithincreasedphysicalsymptomsandalteredT-cel
8、lblastogenesis.Thesedatasuggestthatthehealthimp
