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1、$14InternutionulJournulofInfectiousDiseases(2006)10($1)Abstractsviralload(<16,000copies/10s);Group3(n--4)sta-Objective:Todescribelungtransplantrecipientsble,highviralload(>16,000copiesl10S);Group4chronicallyinfectedbyrhinovirus.(n--4)historyofPTLD,nodetectable/lowviral
2、Methods:Wefirstidentifiedanindexcaseandload.FlowcytometricanalysiswithHLA-A2or-B8confirmedbysequencingviralisolatesthathewastetramer(TMR)probeswasperformedonperiph-chronicallyinfectedbyrhinovirus.Thenwecon-eralblood.ThepolarizationofEBV-specificCD8+Tductedaprospectives
3、tudytoassesstheincidencecells(IFN-glIL-511L-10)wasassessedbyELISPOTorandthepotentialclinicalimpactofchronicrhi-ELISA.noviralinfectionsinacohortof68lungtransplantResults:Overall,the"lytic"specificCD8+Tcellsrecipients.Sequenceanalysisofviralisolates(allweremorefrequentth
4、anthe"latent"onesandcases)aswellimmunochemistryonlungbiopsiesdisplayeddistinctmemoryphenotypes(Effector(inonecase)havebeenperformed.MemoryvsCentralMemory).Inaddition,higherResults:Wedescribe3lungtransplantrecipientsEBVloadstriggeredhigherfrequenciesofTMR+chronicallyinf
5、ectedbyrhinovirusoveraperiodofcells(G2=G3~G1),whilepatientswithhistoryoneyear.RhinoviruswasmainlyidentifiedbyRT-ofPTLD(G4)maintainedhighTMR+frequencies.PCRbutfullvirionswerealsoisolatedrepeatedlyInterestingly,althoughpatientsingroupsG2,G3inonecase.Thepersistenceofauniq
6、uestrainandG4hadhighfrequenciesof"lytic"TMR+cellswasconfirmedbytheanalysisofthe5'NCRand(1.3+2%vs2.3+3.4%vs1.1-1-0.9%),G2andG4ex-VP1genessequencesandruled-outre-infections.hibitedhigherfrequenciesofIFN-yproducingcellsAllcasespresentedlowerrespiratorysymptomsas(30+30and3
7、2+23spots/10s),suggestingfunc-wellasgraftdysfunctions,2hadrepeatedacutetionalEBV-memoryCDS+Tcells,whileG3displayedrejectionsepisodes,and2died.InonecasethatimpairedIFN-y(19+31spots/10s),indicativeoffailedtoproduceneutralizingantibodieswealsofunctionalexhaustion.Although
8、EBVstimulationshowedthepresenceofrhinoviruswithinthelowertriggeredpreponderantlyIFN-y,theIFN-y/IL-5ra-respiratorytrac
