資源描述:
《不同碘營養(yǎng)、不同孕期孕婦的甲狀腺激素變化》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、不同碘營養(yǎng)、不同孕期孕婦的甲狀腺激素變化作者:蘇會(huì)璇,鐘宇華,梁華晟,韋慈,連冬梅【摘要】目的探討北海市不同碘營養(yǎng)狀況、不同孕期孕婦的甲狀腺激素變化及其甲狀腺功能狀態(tài)。方法采用ACS-180化學(xué)發(fā)光分析儀檢測(cè)623例孕婦的血清游離三碘甲狀腺原氨酸(FT3)、游離甲狀腺激素(FT4)、促甲狀腺激素(TSH)和人絨毛膜促性腺激素(hCG);利用碘催化砷鈰反應(yīng)原理,采用冷消解快速尿碘定量檢測(cè)方法測(cè)定孕婦1次隨意尿的尿碘含量。結(jié)果孕早、中期的FT3、FT4和hCG高于孕晚期(P<0.05),而TSH低于孕晚期(P<0.05)。高尿碘組的FT3、FT4和hCG低于正常尿碘
2、、低尿碘組(P<0.05),3組的TSH差異無顯著性(P>0.05)。甲狀腺功能紊亂發(fā)生率為7.54%,不同孕期、不同尿碘組間的甲狀腺功能紊亂發(fā)生率的差異無顯著性(P>0.05)。亞臨床甲狀腺功能減退(甲減)、亞臨床甲狀腺功能亢進(jìn)(甲亢)的發(fā)生率分別為3.53%、2.57%,甲減、甲亢的發(fā)生率分別為1.12%、0.32%。孕早、晚期和各尿碘組均以亞臨床甲減居多,孕中期以亞臨床甲亢居多。結(jié)論碘營養(yǎng)水平及孕期激素變化不是引起孕婦甲狀腺功能紊亂的主要因素,可能妊娠期母體免疫狀態(tài)的改變才是主要的啟動(dòng)因素?!娟P(guān)鍵詞】孕期;碘營養(yǎng);甲狀腺激素;孕婦11 Abstra
3、ct:ObjectiveToinvestigatethevariationsofthyroidhormonelevelsandstatusofthyroidfunctioninpregnantwomenwithdifferentiodinenutritionstatusandinstagesofgestationinBeihai.MethodsFreetriiodothyronine(FT3),freethyroxine(FT4),thyroidstimulatinghormone(TSH)andhumanchoronicgonadotropin(hCG)weredeter
4、minedin623pregnantwomenbyACS-180automaticchemiluninescenceanalyzer.TheurinaryiodinecontentinarandomurinationwasmeasuredusingcolddigestionmethodofrapidquantitativedetectionurinaryiodineaccordingtoiodinecatalyticeffectofArsenic-Cerium.ResultsSerumFT3,FT4andhCGlevelsinthefirstandsecondtrimest
5、erswerehigherthanthoseinthethirdtrimester(P<0.05),andTSHlevelswerelowerthanthoseinthethirdtrimester(P<0.05).FT3,FT4andhCGlevelswerelowerinhighurineiodinegroupthaninnormalandlowurineiodinegroups(P<0.05).Nosignificantdifferenceswerefoundinthe3groups(P>0.05).Theincidenceofthyroidd
6、ysfunctionwas7.54%,withnosignificantdifferencesbetweenthegestationstagesandurineiodinegroups(P>0.05).Theincidenceofsubclinicalhyperthyroidismandsubclinicalhypothyroidismwas3.53%and2.57%,respectivelyandtheincidenceofhyperthyroidismandhypothyroidismwas1.12%and110.32%,respectively.Theincid
7、enceofsubclinicalhyperthyroidismwasdominantintheurinaryiodinegroups,whileinthefirstandthirdtrimesters,theincidenceofsubclinicalhypothyroidismprevailsinthesecondtrimester.ConclusionTheiodinenutritionconditionsandthevariationsofhCGlevelsduringpregnancywerenotthe