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1、膳食干預(yù)腸道菌群預(yù)防代謝性疾病DietaryModulationofGutMicrobiotaforPreventivemanagementofMetabolicDiseases趙立平LipingZhao上海交通大學(xué)生命科學(xué)技術(shù)學(xué)院上海系統(tǒng)生物醫(yī)學(xué)研究中心ShanghaiJiaoTongUniversityHumanSuperorganisms正確認(rèn)識(shí)自己的身體－“超級(jí)生物體”諾貝爾獎(jiǎng)得主-里德伯格,Science2000JoshuaLederbergNobelLaureate1958人體內(nèi)生活著1-2公斤細(xì)菌90%在腸道里人體的細(xì)胞組成10%人細(xì)胞+90%細(xì)菌細(xì)胞人體的基因組成2
2、.5萬個(gè)人的基因3百多萬個(gè)微生物基因豐富而活躍的代謝活動(dòng)腸道菌群——人體后天獲得的“第二個(gè)基因組”GutMicrobiota-Secondgenomeacquiredafterbirth食品藥品人基因組腸道微生物組健康疾病體質(zhì)亞健康先天遺傳后天養(yǎng)成“慢性病的腸道起源” “人體系統(tǒng)生物學(xué)方法”慢性病的腸道起源GutOriginofChronicDiseasesIIyaMechnikovNobelLaureate1908“Laterhetookupthestudyofthefloraofthehumanintestineanddevelopedatheorythatsenilityis
3、duetopoisoningofthebodybytheproductsofcertainofthesebacteria.Topreventthemultiplicationoftheseorganismsheproposedadietcontainingmilkfermentedbybacilliwhichproducelargeamountsoflacticacidandforatimethisdietbecamewidelypopular.”-http://nobelprize.org/Symbiosisvs.Dysbiosis“糞毒入血，百病蜂起”——中醫(yī)觀念“Fecalt
4、oxinsintobloodstreamwillleadtoallkindsofdiseases”——ConceptfromTraditionalChineseMedicine(TCM)細(xì)胞毒素、遺傳毒素、免疫毒素-肝腸循環(huán)-腸屏障受損腸道菌群結(jié)構(gòu)失調(diào)與代謝綜合征Cani,2009腸道菌群控制能量代謝基因表達(dá)Backhed,F.,etal.,Thegutmicrobiotaasanenvironmentalfactorthatregulatesfatstorage.ProcNatlAcadSciUSA,2004.101:15718-15723.Backhed,F.,etal.,Me
5、chanismsunderlyingtheresistancetodiet-inducedobesityingerm-freemice.ProcNatlAcadSciUSA,2007.104:979-984.Turnbaugh,P.J.,etal.,Anobesity-associatedgutmicrobiomewithincreasedcapacityforenergyharvest.Nature,2006.444(7122):p.1027-1031.Turnbaugh,P.J.,etal.,Diet-inducedobesityislinkedtomarkedbutrever
6、siblealterationsinthemousedistalgutmicrobiome.CellHostMicrobe,2008.3:213-223.JefferyGordon肥胖糖尿病炎性衰老低度、系統(tǒng)性的慢性炎癥慢性炎癥與衰老和老年病的關(guān)系InflammationandAge-relatedDiseases代謝性疾病Endotoxin-themostcommonimmunotoxin內(nèi)毒素-最常見的免疫毒素內(nèi)毒素MolecularInflammationinducedbyendotoxin內(nèi)毒素誘導(dǎo)的分子炎癥Inflammationinducedbydiet-disrupt
7、edgutmicrobiota菌群結(jié)構(gòu)失調(diào)誘發(fā)慢性炎癥Cani,P.D.,Amar,J.,Iglesias,M.A.,Poggi,M.,Knauf,C.,Bastelica,D.etal.(2007a)Metabolicendotoxemiainitiatesobesityandinsulinresistance.Diabetes56:1761-1772.Cani,P.D.,Neyrinck,A.M.,Fava,F.,Knauf,C.,Burcelin,R.G.,Tu
