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1、某農村人群甲、乙、丙、戊和庚型肝炎病毒感染的現(xiàn)況研究 【摘要】 目的 了解某農村人群甲、乙、丙、戊和庚型肝炎病毒的感染狀況及其流行特點。方法 應用酶聯(lián)免疫試驗檢測血清抗-HAV、HBsAg、抗-HBs、抗-HBc、抗-HCV、抗-HEV和抗-HGV，并對抗-HGV陽性者應用套式逆轉錄聚合酶鏈反應法檢測HGVRNA。結果 該人群抗-HAV、抗-HCV、抗-HEV和抗-HGV流行率分別為%、%、%和%，HBsAg陽性率為%，HBV總感染率為%。HAV以5歲以下兒童感染率最低，到10歲時%的兒童已感染HAV。HBsAg陽性率呈現(xiàn)兩個高峰，分別在5～9歲和
2、40～49歲年齡組；HBV總感染率到10歲時為%，然后隨年齡增長而上升。HCV感染主要集中在20～49歲年齡組。各型肝炎病毒男女感染率無明顯差異。獻漿次數(shù)、年限與HCV、HEV、HGV感染呈正相關。HBsAg、抗-HBc、抗-HCV呈現(xiàn)家庭聚集性，但僅HBsAg呈現(xiàn)母親與子女相關?？?HCV陽性者中ALT異常率顯著高于抗-HCV陰性者。結論 該人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病學特點；獻血漿是該人群HCV、HEV和HGV感染的主要危險因素；抗-HCV陽性者多伴有肝損害?！ cross-sectionalstudyonHAV,HBV,H
3、CV,HEVandHGVinfectioninaruralpopulation 【Abstract】 Objective TostudytheepidemiologicalcharacteristicsofHAV,HBV,HCV,HEVandHGVinfectionsinaruralpopulation.Methods Enzymeimmunoassayswereusedfordetectionofanti-HAV,HBsAg,anti-HBs,anti-HCV,anti-HEVandanti-HGV.Anti-HGVpositiveseraweref
4、urthertestedforHGVRNAusingareversetranscriptionnestedPCR.Results Theprevalenceratesofanti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGVinthestudiedpopulationwere%,%,%,%and%,respectively.ThetotalinfectionrateofHBVwas%.TheHAVinfectionrateofchildrenbelow5wasthelowestascomparedwithotheragegro
5、ups. %ofchildrenat10yearsoldhadalreadybeeninfectedwithHAV.TheHBsAgpositiverateshowedtwopeaksat5-9and40-49agegroups.ThetotalinfectionrateofHBVwas%intheagegrouplessthan10yearsoldandincreasedwithage.HCVinfectionmainlyoccurredintheagegroupof20-49.Theprevalenceratesofanti-HCV,ant
6、i-HEVandanti-HGVincreasedwiththefrequenciesanddurationofplasmadonation.FamilyclusteringsofHBsAg,anti-HBcandanti-HCVwereobserved.However,onlywithHBsAgshowedacorrelationbetweenmothersandtheirfrequencyofabnormal ALTinanti-HCV positiveindividualswassignificantlyhigherascomparedwithth
7、atinthosewithnegativeanti-HCV.NodifferencewasobservedinthefrequenciesofelevatedALTbetweenthosewithorwithoutHAV,HBV,HEVandHGVmarkers.Conclusion HAV,HBV,HCV,HEVandHGVinfectionshaddifferentepidemiologicalcharacteristics.PlasmadonationwasthemajorriskfactorforHCV,HEVandHGVinfectionsin
8、thispopulationunderstudy.Anti-HCVpositiv
