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《某農(nóng)村人群甲、乙、丙、戊和庚型肝炎病毒感染的現(xiàn)況研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、某農(nóng)村人群甲、乙、丙、戊和庚型肝炎病毒感染的現(xiàn)況研究【摘要】 目的 了解某農(nóng)村人群甲、乙、丙、戊和庚型肝炎病毒的感染狀況及其流行特點(diǎn)。方法 應(yīng)用酶聯(lián)免疫試驗(yàn)(EiA)檢測(cè)血清抗-HAV、HBsAg、抗-HBs、抗-HBc、抗-HCV、抗-HEV和抗-HGV，并對(duì)抗-HGV陽(yáng)性者應(yīng)用套式逆轉(zhuǎn)錄聚合酶鏈反應(yīng)法(RT-nPCR)檢測(cè)HGVRNA。結(jié)果 該人群抗-HAV、抗-HCV、抗-HEV和抗-HGV流行率分別為%、%、%和%，HBsAg陽(yáng)性率為%，HBV總感染率為%。HAV以5歲以下兒童感染率最低(%)，到10歲時(shí)%的兒童已感染HA
2、V。HBsAg陽(yáng)性率呈現(xiàn)兩個(gè)高峰，分別在5～9歲和40～49歲年齡組；HBV總感染率到10歲時(shí)為%，然后隨年齡增長(zhǎng)而上升。HCV感染主要集中在20～49歲年齡組(占%)。各型肝炎病毒男女感染率無(wú)明顯差異。獻(xiàn)漿次數(shù)、年限與HCV、HEV、HGV感染呈正相關(guān)。HBsAg、抗-HBc、抗-HCV呈現(xiàn)家庭聚集性，但僅HBsAg呈現(xiàn)母親與子女相關(guān)。抗-HCV陽(yáng)性者中ALT異常率(%)顯著高于抗-HCV陰性者(%，P＜)。結(jié)論 該人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病學(xué)特點(diǎn)；獻(xiàn)血漿是該人群HCV、HEV和HGV感染的主要危險(xiǎn)因素
3、；抗-HCV陽(yáng)性者多伴有肝損害。Across-sectionalstudyonHAV,HBV,HCV,HEVandHGVinfectioninaruralpopulation 【Abstract】 Objective TostudytheepidemiologicalcharacteristicsofHAV,HBV,HCV,HEVandHGVinfectionsinaruralpopulation.Methods Enzymeimmunoassayswereusedfordetectionofanti-HAV,HBsAg,ant
4、i-HBs,anti-HCV,anti-HEVandanti-HGV.Anti-HGVpositiveserawerefurthertestedforHGVRNAusingareversetranscriptionnestedPCR.Results Theprevalenceratesofanti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGVinthestudiedpopulation%,%,%,%and%,respectively.ThetotalinfectionrateofHBV%.TheHAVi
5、nfectionrateofchildrenbelowwasthelowest(%)ascomparedwithotheragegroups. %ofchildrenat10yearsoldhadalreadybeeninfectedwithHAV.TheHBsAgpositiverateshowedtwopeaksat-and0-4agegroups.ThetotalinfectionrateofHBV%intheagegrouplessthan10yearsoldandincreasedwithage.HCVinfe
6、ctionmainlyoccurredintheagegroupof0-4(%).Theprevalenceratesofanti-HCV,anti-HEVandanti-HGVincreasedwiththefrequenciesanddurationofplasmadonation.FamilyclusteringsofHBsAg,anti-HBcandanti-HCVwereobserved.However,onlywithHBsAgshowedacorrelationbetweenmothersandthEIrfreque
7、ncyofabnormal ALTinanti-HCV positiveindividualswassignificantlyhigherascomparedwiththatinthosewithnegativeanti-HCV.NodifferencewasobservedinthefrequenciesofelevatedALTbetweenthosewithorwithoutHAV,HBV,HEVandHGVmarkers.Conclusion HAV,HBV,HCV,HEVandHGVinfectionshaddiffer
8、entepidemiologicalcharacteristics.PlasmadonationwasthemajorriskfactorforHCV,HEVandHGVinfectionsinthispopulationunderstudy.An
