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1、Anxietydisorders,Obsessive-CompulsiveandRelateddisorders,andTraumaandStressor-relatedDisordersHeidiCombs,MDAssistantProfessorUniversityofWashington/HMCPaulZarkowskiAssistantProfessorAFacultyDisclosureIhavenofinancialrelationshipstodiscloserelatingtothesubje
2、ctmatterofthispresentationWhatwewillreviewEpidemiologyofanxietyandrelateddisordersComorbidpsychiatricdiagnosesDiagnosticcriteriaforanxietyandrelateddisordersNeuroimagingfindingsofanxietydisordersQuickquestionstoscreenforanxietydisordersTreatmentincludingpsy
3、chotherapyandpsychopharmacologyObjectivesListtheprevalenceofanxietyandrelateddisordersIdentifycomorbidpsychiatricdiagnosesPerformaquickscreenforanxietyandrelateddisordersApplygeneralpharmacologicapproachestothetreatmentofanxietydisordersGeneralconsideration
4、sforanxietydisordersOftenhaveanearlyonset-teensorearlytwentiesShow2:1femalepredominanceHaveawaxingandwaningcourseoverlifetimeSimilartomajordepressionandchronicdiseasessuchasdiabetesinfunctionalimpairmentanddecreasedqualityoflifeNormalversusPathologicAnxiety
5、Normalanxietyisadaptive.Itisaninbornresponsetothreatortotheabsenceofpeopleorobjectsthatsignifysafetycanresultincognitive(worry)andsomatic(racingheart,sweating,shaking,freezing,etc.)symptoms.Pathologicanxietyisanxietythatisexcessive,impairsfunction.FocusedNe
6、uroanatomyReviewAmygdala-involvedwithprocessingofemotionallysalientstimuliMedialprefrontalcortex(includestheanteriorcingulatecortex,thesubcallosalcortexandthemedialfrontalgyrus)-involvedinmodulationofaffectHippocampus-involvedinmemoryencodingandretrievalThe
7、differentialdiagnosisofanxiety.PsychiatricandMedicaldisorders.PsychiatrClinNorthAm1985Mar;8(1):3-23PrimaryversusSecondaryAnxietyAnxietymaybeduetooneoftheprimaryanxietydisordersORsecondarytosubstanceabuse(Substance-InducedAnxietyDisorder),amedicalcondition(A
8、nxietyDisorderDuetoaGeneralMedicalCondition),anotherpsychiatriccondition,orpsychosocialstressors(AdjustmentDisorderwithAnxiety)AnxietydisordersSpecificphobiaSocialanxietydisorder(SAD)Panicdisorder(PD)A
