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1、授予單位代碼10089學(xué)號或申請?zhí)?0153474中國圖書分類號R730.5HebeiMedicalUniversity碩士學(xué)位論文專業(yè)學(xué)位腫瘤來源外泌體對宿主免疫狀態(tài)的影響研究生：成士超導(dǎo)師：李中信教授專業(yè)：外科學(xué)二級學(xué)院：第四醫(yī)院2018年3月目錄中文摘要············································································································1英文摘要·································
2、···········································································2英文縮寫············································································································3綜述腫瘤來源外泌體對宿主免疫狀態(tài)的影響··········································4致謝·······················
3、···························································································19個人簡歷··········································································································20中文摘要腫瘤來源外泌體對宿主免疫狀態(tài)的影響摘要外泌體是由活細胞分泌的一種囊泡狀結(jié)構(gòu)，內(nèi)含有母體細胞來源的蛋白質(zhì)、miRNA、mRNA等多種成分
4、，參與細胞間物質(zhì)交換和信息交流。腫瘤來源的外泌體可通過多種機制影響宿主的免疫狀態(tài)，導(dǎo)致腫瘤發(fā)生免疫逃逸。本文重點闡述腫瘤來源外泌體對多種免疫細胞的調(diào)節(jié)作用，包括影響NK細胞的殺傷活性、促進巨噬細胞極化、抑制T細胞增殖、誘導(dǎo)免疫抑制性細胞分化等，旨在深化對腫瘤與免疫之間相互作用的認識，尋求新的免疫治療靶點。關(guān)鍵詞：外泌體，腫瘤，免疫細胞，免疫逃逸，免疫治療1英文摘要TheEffectofTumor-derivedExosomesonImmuneStateoftheHostABSTRACTExosomesareakindofvesicularstru
5、cturesecretedbylivingcells,whichcontainproteins,miRNA,mRNAandothercomponentsderivedfrommatermalcells.Exosomesareimportantmediaforintercellularmaterialexchangeandinformationtransduction.Tumor-derivedexosomescanaffecttheimmunestateofthehostthroughmultiplemechanisms,resultingini
6、mmuneescapeofthetumor.Thepresentstudyfocusesontheregulationoftumor-derivedexosomesonavarietyofimmunecells,includingeffectsonthekillingactivityofNKcells,promotionofmacrophagepolarization,inhibitionofTcellproliferation,inductionofimmunosuppressivecelldifferentiationetc.Weaimtod
7、eepentheunderstandingoftheinteractionbetweentumorandimmunityandtoexplorenovelimmunotherapeutictargets.Keywords:Exosomes,Tumor,Immunocyte,Immuneescape,Immunotherapy2英文縮寫英文縮寫英文縮寫英文全稱中文全稱NKNaturalkillercell自然殺傷細胞MHCMajorhistocompatibilitycomplex主要組織相容性復(fù)合體TLR2Toll-likereceptor2To
8、ll樣受體2MDSCMyeloid-derivedsuppressorcells骨髄來源的抑制性細胞DCDendriticcell樹突狀
