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1、KKME---專業(yè)醫(yī)學(xué)搜索引擎http://www.kkme.net/瑞舒伐他汀對穩(wěn)定型心絞痛PCI病人炎癥因子影響 作者:郝曉燕1,田建會1,趙暉2作者單位:(青島大學(xué)醫(yī)學(xué)院附屬醫(yī)院,山東青島2660031心內(nèi)科;2心電診斷科) 【摘要】目的觀察瑞舒伐他汀對穩(wěn)定型心絞痛病人經(jīng)皮冠狀動脈介入治療(PCI)術(shù)后炎性因子高敏C反應(yīng)蛋白(hsCRP)與白細(xì)胞介素18(IL18)的影響。方法選擇在我院行PCI的40例穩(wěn)定型心絞痛病人為研究對象,隨機(jī)分為治療組和對照組,各20例。在常規(guī)治療的基礎(chǔ)上,治療組PCI前7d開始給予瑞舒伐他汀20mg/d治療,對照組
2、PCI術(shù)后當(dāng)天開始用瑞舒伐他汀。分別于入院時、術(shù)前、術(shù)后24h及術(shù)后28d采集病人空腹靜脈血,測定血清hsCRP、IL18濃度;入院時、術(shù)后28d檢測血脂濃度。結(jié)果治療組和對照組PCI術(shù)前IL18和hsCRP濃度與入院時比較,差異無顯著性(t=0.925~1.362,P>0.05);PCI術(shù)后24h及術(shù)后28d兩組IL18和hsCRP濃度較入院時均增高,差異有統(tǒng)計學(xué)意義(t=2.167~6.747,P<0.05)。治療組入院時和術(shù)前IL18、hsCRP濃度與對照組比較,差異無統(tǒng)計學(xué)意義(t=0.320~0.910,P>0.05);術(shù)后24h,
3、治療組IL18、hsCRP的濃度較對照組降低,差異有統(tǒng)計學(xué)意義(t=2.320、2.059,P<0.05);術(shù)后28d,治療組IL18的濃度較對照組降低,差異有統(tǒng)計學(xué)意義(t=2.174,P<0.05),兩組hsCRP的濃度差異無統(tǒng)計學(xué)意義(t=0.201,P>0.05)。治療組和對照組入院時和術(shù)后28d的血脂濃度比較,差異均無統(tǒng)計學(xué)意義(t=0.522~1.322,P>0.05)。結(jié)論P(yáng)CI可以導(dǎo)致血清hsKKME---專業(yè)醫(yī)學(xué)搜索引擎http://www.kkme.net/CRP和IL18水平升高;早期應(yīng)用瑞舒伐他汀可明顯控制PCI術(shù)后血清h
4、sCRP、IL18水平的上升,從而減少心血管事件的發(fā)生?! 娟P(guān)鍵詞】心絞痛;瑞舒伐他汀;血管成形術(shù),經(jīng)腔,經(jīng)皮冠狀動脈;C反應(yīng)蛋白;白細(xì)胞介素18 EFFECTOFROSVASTATINONINFLAMMATORYCYTOKINEINPATIENTSWITHSTABLEANGINAUNDERGOINGPERCUTANEOUSCORONARYINTERVENTIONHAOXIAOYAN,TIANJIANHUI,ZHAOHUI(DepartmentofCardiology,TheAffiliatedHospitalofQingdaoUniversit
5、yMedicalCollege,Qingdao266003,China);[ABSTRACT]ObjectiveToinvestigatetheeffectofrosvastatinonserumhighsensitiveCreactiveprotein(hsCRP),interleukin18(IL18)andlipidsinpatientswithstableangina(SA)undergoingpercutaneouscoronaryintervention(PCI).MethodsThisstudyincluded40patientswi
6、thSAundergoingPCI,whowereevenlyrandomizedtotreatmentgroupandcontrolgroup.Aconventionaltherapywasofferedtobothgroups.Forthoseintreatmentgroup,rosvastatin(20mg/day)wasadded,startingfrom7daysbeforePCI,andforthoseinthecontrol,rosvastatinstartingfromthedayoftheprocedure.TheserumhsCRP,I
7、L18andlipidsweremeasuredonadmission,beforeand24hoursaswellas28daysafterPCI.ResultsPreoperatively,thedifferencesofhsCRPandIL18betweenthetwogroupsonadmissionwerenotsignificant(t=0.925-1.362,P>0.05).Postoperativelyfor28hoursand28KKME---專業(yè)醫(yī)學(xué)搜索引擎http://www.kkme.net/days,thelevelsofhs
8、CRPandIL18ofthebothgroup