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1、血清降鈣素原檢測在細菌性感染疾病早期診斷中的臨床應(yīng)用【摘要】目的探討血清降鈣素原（PCT）檢測在細菌性感染疾病早期診斷中的臨床應(yīng)用價值。方法選取347例感染性疾病患者為研究對象，根據(jù)病原學和血清免疫學確診實驗分為細菌性感染組（212例）和病毒性感染組（135例）。采用ATB細菌鑒定分析系統(tǒng)進行細菌培養(yǎng)及鑒定；采用乳膠增強免疫散射比濁法在羅氏CobasE411型全口動電化學發(fā)光免疫分析儀上測定血清PCT和C反應(yīng)蛋白（CRP）水平；統(tǒng)計對比分析各組指標的檢測結(jié)果。結(jié)果細菌性感染組中，PCT檢測結(jié)果陽性率為86.79%,明顯高于病毒性感染組的6.67
2、%（x2=214.519,P<0.001）,且與細菌培養(yǎng)結(jié)果比較差異無統(tǒng)計學意義（x2二0.125,P=0.724）oROC曲線分析結(jié)果顯示,CRP、PCT、WBC及ESR的ROC曲線下面積分別為0.805、0.912、0.787和0.673,標準誤（s）分別為0.050、0.053、0.041和0.028,95%置信區(qū)間分別為0.731?0.892、0.877?0.964、0.693—0.835和0.612?0.763。結(jié)論PCT不僅可以作為早期診斷細菌性感染的特異性指標，還可用于細菌性感染與病毒性感染的鑒別診斷，同時動態(tài)監(jiān)測PCT水平變化對
3、治療細菌性感染也有一定的指導作用，值得臨床推廣應(yīng)用?！娟P(guān)鍵詞】降鈣素原；感染性疾??；細菌感染；病毒感染[Abstract】ObjectiveToinvestigatetheclinicalvalueofdetectionofscrumprocalcitonin(PCT)inearlydiagnosisofbacterialinfection.MethodsAtotalof347patientswithinfectiousdiseaseswereselectedasresearchobjects,anddividedintobacterialin
4、fectiongroup(n=212)andviralinfectiongroup(n=135)?BacterialcultureandidentificationworecarriedoutbyATBbacterialidentificationandanalysissystem.TheserumlevelsofPCTandC~reactiveprotein(CRP)weremeasuredbylatexenhancedimmunescatteringturbidimetryonRocheCobasE411automatedelectroch
5、em訂uminescenceimmunoassayinstrument?Inaddition,SPSS13statisticalsoftwarewasadoptedtocompareandanalyzethetestresultsofeachgroup.ResultsInthebacterialinfectiongroup,thepositiverateofPCTtestwas86.79%,whichwashigherthanthat(6.67%)ofviralinfectiongroup(x2=214.519,P〈0?001),andcomp
6、aredwithbacterialcultureresults,differencewasnotstatisticallysignificant(x2=0.125,P=0.724)?ROCcurveanalysisresultsalsoshowedthattheareaofROCcurveofCRP,PCT,WBCandESRwererespectively0.805,0.912,0.787and0.673,standarderror(s)wererespectively0.050,0.053,0.041and0.028,and95%confi
7、denceintervalswererespectively0.731~0.892,0.877~0.964,0.693?0.835and0.612~0.763.ConclusionPCTcannotonlybeusedasaspecificmarkerforearlydiagnosisofbacterialinfection,butalsofordifferentidldiagnosisofbacterialinfectionandviralinfection.AnddynamicmonitoringofthelevelsofPCTchange
8、salsomakecertainguidanceforthetreatmentofbacterialinfection,andthusitiswort
