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1、厄貝沙坦聯(lián)合美托洛爾治療慢性充血性心衰的療效觀察［摘要］目的探討厄貝沙坦聯(lián)合美托洛爾治療慢性充血性心衰的療效。方法將2014年1月?2016年10月在我院老年醫(yī)學(xué)科治療的280例慢性充血性心衰患者隨機(jī)分為兩組，對(duì)照組給予常規(guī)治療，觀察組在此基礎(chǔ)上給予厄貝沙坦聯(lián)合美托洛爾治療，比較兩組患者的臨床療效、左心功能改善情況、心率及血壓情況。結(jié)果觀察組臨床有效率為95.00%,明顯高于對(duì)照組的80.71%,兩組差異有統(tǒng)計(jì)學(xué)意義;觀察組治療后LVEF、LVEDd、LVESd明顯較對(duì)照組改善，兩組差異有統(tǒng)計(jì)學(xué)意義；觀察組治療后HR、DBP、SBP明顯低于對(duì)照組，兩組差異有統(tǒng)計(jì)
2、學(xué)意義；兩組間不良反應(yīng)發(fā)生率無(wú)明顯差異。結(jié)論厄貝沙坦聯(lián)合美托洛爾治療慢性充血性心衰效果明確，利于降低心率和血壓，改善左心功能，具有積極的臨床意義。［關(guān)鍵詞］慢性充血性心衰；厄貝沙坦；美托洛爾；療效觀察［中圖分類號(hào)］R541.6+1［文獻(xiàn)標(biāo)識(shí)碼］B［文章編號(hào)］1673-970118-0088-03ClinicalobservationofirbesartancombinedwithmetoprololinthetreatmentofchroniccongestiveheartfailureCHENXiaoyongZHANGLingliLINZiweiDepartm
3、entofGeneralMedicine，BozhouCityPeople’sHospitalofAnhuiProvince，Bozhou236800,China[Abstract]ObjectiveToinvestigatetheclinicaleffectofirbesartancombinedwithmetoprololinthetreatmentofchroniccongestiveheartfailure.MethodsAtotalof280patientswithchroniccongestiveheartfailurewhoweretreatedi
4、nthedepartmentofgeriatricsfromJanuary2014toOctober2016wererandomlydividedintotwogroups.Thecontrolgroupreceivedconventionaltherapy，theobservationgroupwastreatedwithirbesartancombinedwithmetoprololbasedonthetreatmentofthecontrolgroup.Theclinicalefficacy，leftheartfunctionimprovement，hea
5、rtrateandbloodpressurebetweenthetwogroupswerecompared.ResultsTheclinicaleffectiveratewas95%intheobservationgroup，significantlyhigherthan80.71%inthecontrolgroup,andthedifferencewasstatisticallysignificant.TheLVEF，LVEDdandLVESdintheobservationgroupweresignificantlyhigherthanthoseinthec
6、ontrolgroupaftertreatment，andthedifferencewasstatisticallysignificant.TheHR，DBPandSBPintheobservationgroupweresignificantlylowerthanthoseofthecontrolgroup，andthedifferencewasstatisticallysignificant.Therewasnosignificantdifferenceintheincidenceofadversereactionsbetweenthetwogroups.Co
7、nclusionsIrbesartancombinedwithmetoprololiseffectiveinthetreatmentofchroniccongestiveheartfailure,whichisbeneficialtoreduceheartrateandbloodpressureandimprovesleftventricularfunction.Ithaspositiveclinicalsignificance.[Keywords]Chroniccongestiveheartfailure；Irbesartan;Metoprolol；Effic
8、acyobservati
