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1、單采血小板輸注無(wú)效原因分析及臨床對(duì)策吉林大學(xué)第四醫(yī)院輸血科吉林省長(zhǎng)春市130011摘要:目的分析臨床單采血小板輸注無(wú)效的原因,為臨床科學(xué)、合理、有效使用血小板提供參考依據(jù)和對(duì)策。方法對(duì)46例115例次輸注單采血小板患者按不同疾病和輸注頻率分組進(jìn)行統(tǒng)計(jì)分析,計(jì)算血小板校正增加指數(shù)(CCI)來(lái)判斷臨床療效。結(jié)果血液腫瘤病患者輸注血小板無(wú)效率明顯高于外科手術(shù)及其他疾病患者,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)o低頻組血小板輸注有效率高于高頻組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)o結(jié)論影響血小板輸注療效的因素很多。隨著輸注頻率的增加,血小板輸注有效率逐漸下降,易產(chǎn)生血小板抗體,出現(xiàn)血小板輸注無(wú)效
2、(PTR),臨床應(yīng)進(jìn)行配合型血小板輸注。關(guān)鍵詞:?jiǎn)尾裳“澹谎“遢斪o(wú)效:血小板校正增加指數(shù)Abstract:ObjectiveToprovideevidenceandmeasuresforthescientific,reasonableandeffectiveclinicaluseofplateletthroughobservingandanalyzingtheclinicalcurativeeffectofplateletstransfusion.MethodsStatisticalanalysiswerecarriedoutfor46platelettransfusedpatients
3、(115times)accordingtodifferentdiseasesandtransfusionfrequency,theperipheralplateletswerecountedbeforetransfusionand24haftertransfusion,theclinicaleffectswereevaluatedaccordingtothecorrectedcountincrement(CCI).ResultsTheplatelettransfusionefficiencyinpatientswithhematologicdiseasesandtumorswaslowerth
4、anthosesufferedfromsurgicaloperationsandotherdiseases.Therewasstatisticalsignificanceinthedifference(P<0.05).Platelettransfusionefficiencyoflowfrequencygroupswashigherthanhighfrequencygroups,thedifferenceshadstatisticalsignificances(P<0.05).ConclusionsThereweremanyreasonsonthecurativeeffectofp
5、latelettransfusion.Thecurativeeffectofplatelettransfusionisdifferentindifferentdiseases.Withtheincreaseoftransfusionfrequency,platelettransfusionefficiencydecreasesgraduallyandevenappearsplateletantibodiesandplatelettransfusionrefractoriness(PTR).Plateletstransfusionshouldbecoordinated.Keywords:plat
6、elet;platelettransfusionrefractoriness(PTR);correctedcountincrement(CCI)臨床治療性血小板輸注顯著增多,但多次反復(fù)輸注血小板的患者,其臨床療效卻不同,甚至出現(xiàn)血小板輸注無(wú)效(PTR),即患者連續(xù)兩次輸注足量隨機(jī)供者血小板后,沒(méi)有達(dá)到合適的校正血小板增高指數(shù)值(CCI),臨床表現(xiàn)亦未有改善[1]。預(yù)防和治療PTR己成為臨床輸血的棘手問(wèn)題。為科學(xué)、合理、有效使用血小板,預(yù)防和治療PTR提供參考依據(jù)和對(duì)策,現(xiàn)就我院血小板輸注療效情況及原因分析報(bào)告如下:1資料與方法1.12014年1月至11月本院輸注單采血小板的住院患者46例,其中
7、男25例,女21例,年齡在6?97歲。按疾病分組:血液腫瘤病26例,外科手術(shù)13例,其他疾病7例。按輸注頻率分組:輸注1?3次為低頻組38例,輸注≥5次為高頻組8例。共輸注血小板115例次。1.2單采血小板來(lái)源及輸注指征單采血小板全部由長(zhǎng)春市中心血站提供(效期5天),1個(gè)治療量血小板≥2.5×1011/袋。內(nèi)科血小板計(jì)數(shù)<20×109/L,外科手術(shù)血小板計(jì)