資源描述：
《dl1的表達(dá)和基因多態(tài)性在胃癌中的診斷及預(yù)后價值的研究》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、第三軍醫(yī)大學(xué)碩士學(xué)位論文ThevaluestudyofPD-L1expressionandgenepolymorphismofthediagnosisandprognosisingastriccancer．AbstractBackgroundandobjectiveGastriccancer(GC)isoneofthemostcommonfatalcancers，Theincidenceforgastriccarcinomahashadarecentincrease．Effectivemethodsforearlydiagnosis，m
2、onitoringmetastasis，andprognosisarecurrentlyunavailableforgastriccancer．Immunotherapyhasshownbrightpromiseinthetreatmentofgastriccancer．Unfortunately，itwasreportedthatgastriccancercellScanescapeimmunesurveillancebyavarietyofmechanismswhichpreventtheimmunesystemfromproduc
3、ingeffectiveantitumorimmuneresponses．SomestudieshavereportedthatPD-L1increasesapoptosisofantigen—specifichumanT-cellclonesandinhibitstheactivationofCD4andCD8T-cellsinvitro．MoreoverPD—L1highexpressioninthemultipletumor，includinggastriccancer．SeveralstudieshaveshownthatPD·
4、-1orPD··L1antibodiescouldrelievetheinhibitoryeffectsofPD-L1oncytotoxicT-cellsandhenceacceleratetheremovaloftumorcellsbycytotoxicT-cellsandinterruptingthePD1／PD·L1signalpathwayisapromisingtherapeuticstrategyforcancer．Apurinic／apyrimidinicendonuclease1(APE1)playsanimportan
5、troleinmultiplebiologicalprocesses。ItcanrepairDNAdamageandsuppresstumorigenesisthroughmaintaininggenomestability．APE1，asaredox—activeprotein，alsoactivatesmanytranscriptionfactors．APE1overexpressionenhancedthetumorigenesisofgastriccancer．SNPisoneoftheimportantfactorsforca
6、ncersusceptibility．SeveralpolymorphismsinexonsofPD．Llhavebeendescribedandrelatedwithautoimmunediseases．However，theSNPofPD—L1forgastriccanceralsorarelyreported．Inpartone，wedetectedtheassociationbetweentheexpressionofPD—L1andAPElwiththegastriccancerpatientswith107cases．And
7、thenThePCR—CTPPwasconductedtoanalyzetheassociationsofgastriccancersusceptibilitywithPD—L1genesinglenucleotide2萬方數(shù)據(jù)第三軍醫(yī)大學(xué)碩士學(xué)位論文polymorphism．ToprovidetheoreticalsupportforthePD—L1asatargetinimmunetherapeuticofgastriccancer，MethodsThisprogramconsistedoftwoparts．Inthepartone
8、，theexpressionofPD—L1andAPElin107gastriccancertissueswereevaluatedbyIHC．Observetheexpressionofthesetwog
