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1、經(jīng)尿道電切綜合征模型的建立和心功能評(píng)價(jià)來源：醫(yī)學(xué)論文發(fā)表——?jiǎng)?chuàng)新醫(yī)學(xué)網(wǎng)http://www.yixue360.com/　　作者：馮艷紅作者單位：遼寧醫(yī)學(xué)院附屬第一醫(yī)院泌尿外科，遼寧錦州121001　　【摘要】目的以5%甘露醇沖洗液建立犬經(jīng)尿道電切綜合征(TURS)模型，探討TURS對(duì)心功能影響。方法家犬8只，以100mL/min速度靜脈輸入5%甘露醇沖洗液3000mL，建立犬TURS模型;于輸液前和輸液后10、20、30、60min，測(cè)定心功能，血清鉀、鈉、氯濃度，心肌酶譜，心電圖，并進(jìn)行病理觀察。結(jié)果心率、左室舒張期末內(nèi)徑、收

2、縮期末內(nèi)徑在30min時(shí)增加(P值均<0.05)，收縮壓、舒張壓、脈壓和射血分?jǐn)?shù)30min時(shí)降低(P值均<0.05)。血清天冬氨酸轉(zhuǎn)氨酶、乳酸脫氫酶、肌酸激酶和肌酸激酶同工酶在60min時(shí)的變化無統(tǒng)計(jì)學(xué)意義(P>0.05)。TURS時(shí)心電圖可有心律不齊和心肌缺血改變。病理觀察示心肌纖維間充血和局部變性，肺臟水腫。結(jié)論TURS可引起心功能改變，并造成心肌損傷。發(fā)生TURS時(shí)心率和血壓的改變出現(xiàn)較早，應(yīng)足夠重視，并及時(shí)的檢測(cè)血清離子。　　【關(guān)鍵詞】經(jīng)尿道電切綜合征水中毒心功能心肌酶譜犬　　EstablishmentoftheTran

3、surethralProstateResectionSyndromeModelandtheEvaluationonCardiacFunction醫(yī)學(xué)論文發(fā)表——?jiǎng)?chuàng)新醫(yī)學(xué)網(wǎng)http://www.yixue360.com/　　FENGYanhong，JIANGHuamao，ZHANGChunyang，ZHANGDatian，LIUYan　　DepartmentofUltrasound,theFirstAffiliatedHospitalofLiaoningMedicalUniversity，Jinzhou121001China　　A

4、bstract:ObjectiveToestablishthetransurethralprostateresectionsyndromemodelindogsandprobeintotheeffectsoncardiacfunctionofthemodelsofTURS.MethodsWeestablishedanimalmodelsineightdogsbyintravenousinjectionsof3000mL5%Mannitolat100mL/min.Cardiacfunctionandelectrocardiogra

5、mwereexaminedbeforeandafter10,20,30and60minuteswhenserumdielectrics,myocardialenzymesweremeasured.Samplesofthecardiacmuscleandlungweretakenout60minutesafterthedrugadministrationandwereobservedthehistologicalchanges.ResultsHeartrate,leftventricularend-diastolicdimensi

6、onandleftventricularend-systolicdimensionwereincreased30minutesafteradministration(P<0.05),systolicbloodpressure,diastolicbloodpressurepulsepressureandejectionfractionandshorteningfractionbutdecreasedin30minutes(P<0.01).Theserumsodium,potassiumandchloridelevelswerede

7、creasedatanytimepoints,butthechangesofmyocardialenzymeswereinsignificantlyin60minutesafter醫(yī)學(xué)論文發(fā)表——?jiǎng)?chuàng)新醫(yī)學(xué)網(wǎng)http://www.yixue360.com/administration(P>0.05).Thereweresuchchangesasanisorhythmia,myocardialischemiainelectrocardiogram.Pathologicalexaminationrevealedhyperaemiaam

8、ongmyocardialfiberscardiacmusclefibers,partapomorphosisandedemaoflung.ConclusionsTURSmaycausechangesoncardiacfunctionandmyocardiald