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1、萬方數(shù)據(jù)分與神經(jīng)生長一l(netrin-1)之間以及二者與各心臟代謝指標(biāo)的相關(guān)分析。并未發(fā)現(xiàn)Gensini評分與神經(jīng)生長．1(netrin-1)之間具有顯著地相關(guān)性仁一0．129p=0．329)，也未發(fā)現(xiàn)各心臟代謝指標(biāo)與神經(jīng)生長一1(netrin—1)以及Gensini評分有顯著相關(guān)性。結(jié)論：我們的研究再次證實了其他相關(guān)研究之前證實的結(jié)論：盡管在粥樣斑塊的形成及其不穩(wěn)定性中，神經(jīng)生長因子．1(netrin一1)具有重要作用，但是冠心病人群與無冠心病人群之間血漿神經(jīng)生長因子一1(netrin-1)的濃度卻并無顯著差異性。神經(jīng)生長因子一l(Netri
2、n-1)與Gensini評分及相關(guān)心臟代謝參數(shù)之間也無相關(guān)性。這一發(fā)現(xiàn)提示當(dāng)前神經(jīng)生長因子一1(Netrin一1)還不能作為診斷冠心病的標(biāo)志物。但是，神經(jīng)生長因子一1仍是心血管領(lǐng)域中值得探索的物質(zhì)，因為其不僅與動脈粥樣斑塊的形成，不穩(wěn)定性及脆性相關(guān)，而且在心肌梗死后血管新生及抑制和心肌保護方面亦有廣闊的探索空間。(圖6幅，表3個，參考文獻90篇，副表1個)關(guān)鍵詞：動脈粥樣硬化；冠狀動脈疾??；Gensini評分；神經(jīng)生長因子．1分類號：R246．1IV萬方數(shù)據(jù)Plasmaconcentrationofnetrin一1inpatientswithco
3、ronaryAbstractarterydiseaseanditsassociationwithcoronaryarterystenosisBackgroundandobjectivesCoronaryarterydisease(CAD)ischaracterizedbyatherosclerosisintheepicardialcoronaryarteries．Atheroscleroticplaques，thehallmarkofatherosclerosis，progressivelynarrowthecoronaryarterylumen
4、andimpairantegrademyocardialbloodflow．Atherosclerosisisadiseaseofchronicinflammationthatisdistinguishedbythepersistenceofcholesterol—engorgedmacrophagesinarterialplaques．Thesemacro—phagesalsoknownasthemajorsourcesoffoamcellscauseexpansionoftheplaquethroughrecruitmentofadditio
5、nalleukocytesandvascularsmoothmusclecells．Resolutionofacuteinflammationtypicallyinvolvesemigrationofmonocyte—derivedcellsoutoftheinflamedsitethroughnearbylymphaticvessels．Thisprocessappearstobeimpairedinatherosclerosisandhasbeenattributed，inpart，tothecholesterolloadingofmacro
6、phageswhichshiftsthesecellstoamoresessilephenotype．Ithasbeenproveninvitroandinanimalstudiesthatmacrophage·-engorged--cholesterolintheatheromahighlyexpressesnetrin一1resultingintheatheromaprogressionandtherebypromotionofatherosclerosis．Howeverstudiesinhumansremainscarcetherefor
7、eOurstudyaimedtoassesstheassociationbetweenplasmanetrin一1levelandtheseverityofcoronaryarterydiseaseusingtheGensiniscoresystem．MaterialsandmethodsV萬方數(shù)據(jù)Ourpopulationiscomposedof88patientsfromthedepartmentofcardiovasculardiseaseatthesecondXiangYahospitalofcentralsouthuniversityo
8、fChangshawhounderwentcoronaryangiography(CAG)．Allsubjectswereprogram
