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1、健脾益氣中藥對脾虛大鼠骨骼肌線粒體損傷的保護作用宋雅芳1劉友章2黃曉燕1姬愛冬1宋雅芳，黃曉燕，姬愛冬，廣州中醫(yī)藥大學，廣東省廣州市510405劉友章，廣州中醫(yī)藥大學第一附屬醫(yī)院，廣東省廣州市510405作者貢獻分布：此課題由宋雅芳及劉友章設計；研究過程由宋雅芳與黃曉燕、姬愛冬操作完成；研究所用試劑及分析工具由宋雅芳提供；數(shù)據分析由宋雅芳完成；本論文寫作由宋雅芳、黃曉燕完成。廣州中醫(yī)藥大學博士后科研基金資助通訊作者：劉友章，510405，廣東省廣州市機場路12號，廣州中醫(yī)藥大學第一附屬醫(yī)院.liu408@126.com電話：020-36591135Theprotectionofinvig
2、oratingthespleenandtonifyingQiherbsonimpairedmitochondriaofskeletalmuscleinratswithspleenastheniaYa-FangSong,You-ZhangLiu,Xiao-YanHuang,Ai-DongJiYa-FangSong,Xiao-YanHuang,Ai-DongJi,GuangzhouuniversityofChineseMedicine,Guangzhou510405,Guangdongprovince,ChinaYou-ZhangLiu,Thefirstaffiliatedhospitalo
3、fGuangzhouuniversityofChineseMedicine,Guangzhou510405,Guangdongprovince,ChinaSupportedby:Post-doctorscientificresearchfoundationofGuangzhouuniversityofChineseMedicineCorrespondenceto:You-zhangLiu,thefirstaffiliatedhospitalofGuangzhouuniversityofChineseMedicine,Guangzhou510405,Guangdongprovince,Ch
4、ina.Liu408@126.comAbstractAIM:ToobservetheeffectsofinvigoratingthespleenandtonifyingQiherbsonmitochondriasuccinatedehydrogenase,cytochromeoxidaseactivityofskeletalmuscleinratswithspleenasthenia.METHODS:TheratsinthemodelgroupwerefedwithhalffullandperfusewithXiaochengqiDecoctioneverydaytobuildanima
5、lmodelofspleenasthenia.40SDratswererandomlydividedinto4groups:normalcontrolgroup,modelofspleenastheniagroup,sijunzidecoctiongroupandhuangqisijunzidecoctiongroup.Generalstateofratswereobserved,thechangesofmitochondriasuccinatedehydrogenase,cytochromeoxidaseactivityofskeletalmuscleweremeasuredbybio
6、chemicalmethod.8RESULTS:Comparedwithnormalcontrolgroup,thelevelofSDHandcytochromeoxidaseactivityofskeletalmusclemitochondriainspleenastheniagroupweredecreasedobviously（27.112±7.104VS44.328±5.894,3.029±0.501VS4.455±0.767,bothP＜0.01）；WhileHuangqisijunzidecoctiongroupandsijunzidecoctiongroupcanenhan
7、cethelevelofSDH（41.426±4.700VS27.112±7.104，38.419±3.873VS27.112±7.104，bothP＜0.01）andcytochromeoxidaseactivityofskeletalmusclemitochondriacomparedwithmodelgroup（4.234±0.577VS3.029±0.501，4.002±0.491VS3.029±0.501，bothP＜0.
