notch信號(hào)途徑對(duì)小鼠骨髓單核來(lái)源樹(shù)突狀細(xì)胞和巨噬細(xì)胞分化發(fā)育的調(diào)控

《notch信號(hào)途徑對(duì)小鼠骨髓單核來(lái)源樹(shù)突狀細(xì)胞和巨噬細(xì)胞分化發(fā)育的調(diào)控》由會(huì)員上傳分享，免費(fèi)在線(xiàn)閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。

1、獨(dú)創(chuàng)性聲明秉承學(xué)校嚴(yán)謹(jǐn)?shù)膶W(xué)風(fēng)與優(yōu)良的科學(xué)道德，本人聲明所呈交的論文是我個(gè)人在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果。盡我所知，除了文中特別加以標(biāo)注和致謝的地方外，論文中不包含其他人已經(jīng)發(fā)表或撰寫(xiě)過(guò)的研究成果，不包含本人或他人已申請(qǐng)學(xué)位或其他用途使用過(guò)的成果。與我一同工作的同志對(duì)本研究所做的任何貢獻(xiàn)均已在論文中作了明確的說(shuō)明并表示了致謝。申請(qǐng)學(xué)位論文與資料若有不實(shí)之處，本人承擔(dān)一切相關(guān)責(zé)任。論文作者簽名：日期：保護(hù)知識(shí)產(chǎn)權(quán)聲明本人完全了解第四軍醫(yī)大學(xué)有關(guān)保護(hù)知識(shí)產(chǎn)權(quán)的規(guī)定，即：研究生在校攻讀學(xué)位期間論文工作的知識(shí)產(chǎn)權(quán)單位屬第四軍醫(yī)大學(xué)。本人保證畢業(yè)離校后，發(fā)表論文或使用論文工作

2、成果時(shí)署名單位仍然為第四軍醫(yī)大學(xué)。學(xué)?？梢怨颊撐牡娜炕虿糠謨?nèi)容（含電子版，保密內(nèi)容除外），可以采用影印，縮印或其他復(fù)制手段保存論文。學(xué)校有權(quán)允許論文被查閱和借閱，并在校園網(wǎng)上提供論文內(nèi)容的瀏覽和下載服務(wù)。同意學(xué)校將論文加入《中國(guó)優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫(kù)》和編入《中國(guó)知識(shí)資源總庫(kù)》，同意按《中國(guó)優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫(kù)出版章程》規(guī)定享受相關(guān)權(quán)益。論文作者簽名：導(dǎo)師簽名：日期：Notch信號(hào)途徑對(duì)小鼠骨髓單核來(lái)源樹(shù)突狀細(xì)胞和巨噬細(xì)胞分化發(fā)育的調(diào)控研究生：王耀春學(xué)科專(zhuān)業(yè)：發(fā)育生物學(xué)所在單位：第四軍醫(yī)大學(xué)基礎(chǔ)部醫(yī)學(xué)遺傳學(xué)與發(fā)育生物學(xué)教研室導(dǎo)師：韓驊教授（主任）資助基金項(xiàng)目：

3、“973”計(jì)劃子項(xiàng)目(NO.2009CB521706)國(guó)家杰出青年基金(NO.30425015)國(guó)科金重點(diǎn)項(xiàng)目(NO.30830067)第四軍醫(yī)大學(xué)博士資助項(xiàng)目(NO.2007D05)關(guān)鍵詞：Notch信號(hào)途徑；RBP-J；單核細(xì)胞；樹(shù)突狀細(xì)胞；CXCR4；巨噬細(xì)胞中國(guó)人民解放軍第四軍醫(yī)大學(xué)2009年5月目錄縮略語(yǔ)表··············································································································1中文摘要··················

4、····························································································3英文摘要··············································································································6前言··················································································

5、··························10文獻(xiàn)回顧············································································································12正文············································································································53第一部分NOTCH信號(hào)途徑對(duì)于小鼠單核細(xì)胞分化方向的影響··········

6、············531實(shí)驗(yàn)材料和主要儀器··············································································532實(shí)驗(yàn)方法·································································································553實(shí)驗(yàn)結(jié)果···············································································

7、··················604討論·········································································································64第二部分NOTCH信號(hào)途徑對(duì)于小鼠DC發(fā)育和功能的影響·····························671實(shí)驗(yàn)材料和主要儀器··················································