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《螺內(nèi)酯對醛固酮誘導(dǎo)的大鼠腎小球系膜細胞氧化應(yīng)激及nf-κb、mcp-1表達的影響》由會員上傳分享,免費在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、目錄中英文縮略詞表…………………………………………………………2中文摘要…………………………………………………………………4英文摘要…………………………………………………………………7引言………………………………………………………………………11材料與方法………………………………………………………………12結(jié)果………………………………………………………………………24討論………………………………………………………………………32結(jié)論………………………………………………………………………39參考文獻………………………………………………………………
2、…40附錄個人簡歷…………………………………………………………45致謝………………………………………………………………………47綜述………………………………………………………………………481中英文及縮寫對照表縮寫英文名稱中文名稱ACEIangiotensinconvertingenzymeinhibitor血管緊張素轉(zhuǎn)換酶抑制劑ACRalbumin-to-creatinineratio尿白蛋白/肌酐比值A(chǔ)GEsadvancedglycosylationendproducts糖基化終末產(chǎn)物ALDaldosterone醛固酮AngⅡangiote
3、nsinⅡ血管緊張素ⅡAP-1activatorprotein-1活化蛋白-1ARaldosereductase醛糖還原酶ARBangiotensionⅡreceptorblocker血管緊張素Ⅱ受體拮抗劑CATcatalase過氧化氫酶CCR2C-Cchemokinereceptor-2CC類趨化因子受體2CTGFconnectivetissuegrowthfactor結(jié)締組織生長因子DCFH-DA2’,7’-dichlorofluoresceindiacetate2',7'-二氯雙氫熒光素二乙酸酯DMdiabetesmellitus糖尿病D
4、Ndiabeticnephropathy糖尿病腎病ECMextracellularmatrix細胞外基質(zhì)ERKextracellularsignal-regulatedkinase細胞外信號調(diào)節(jié)激酶FDAfoodanddrugadministration(美國)食品和藥物管理局FNfibronectin纖維連接蛋白GAPDHglyceraldehydephosphatedehydrogenase磷酸甘油醛脫氫酶GBMglomerularbasementmembrane腎小球基底膜Gly-Albglycosylation-albumin糖基化白蛋
5、白GPxglutathioneperoxidase谷胱甘肽過氧化物酶GRglucocorticoidreceptor糖皮質(zhì)激素受體GSHglutathione還原型谷胱甘肽ICAM-1intercellularadhesionmolecule-1細胞間黏附分子-12IL-6interleukin-6白介素-6MAPKmitogen-activatedproteinkinases絲裂原活化蛋白激酶MCP-1monocytechemoattractantprotein-1單核細胞趨化蛋白-1MCsmesangialcells系膜細胞MDAmalon
6、dialdehyde丙二醛MIFmacrophagemigrationinhibitoryfactor巨噬細胞游走抑制因子MRmineralocorticoidreceptor醛固酮受體NACN-acetylcysteineN-乙酰半胱氨酸NF-κBnuclearfactor-κB核因子-κBOx-LDLoxidizedlowdensitylipoprotein氧化低密度脂蛋白PAI-1plasminogenactivatorinhibitor-1纖溶酶原激活物抑制物-1PKCproteinkinaseC蛋白激酶CRAASrenin-angio
7、tensin-aldosteronesystem腎素-血管緊張素-醛固酮系統(tǒng)ROSreactiveoxygenspecies活性氧RT-PCRreversetranscription-polymerasechain逆轉(zhuǎn)錄聚合酶鏈反應(yīng)reactionSODsuperoxidedismutase超氧化物歧化酶SPIspironolactone螺內(nèi)酯SPSSstatisticalpackageforsocialscience社會科學(xué)統(tǒng)計軟件包TGF-β1transforminggrowthfactor-β1轉(zhuǎn)化生長因子-β111β-HSD211β-h
8、ydroxysteroiddehydrogenase211β-羥類固醇脫氫酶23螺內(nèi)酯對醛固酮誘導(dǎo)的大鼠腎小球系膜細胞氧化應(yīng)激及NF-κB、MCP-1