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《兔脛骨牽張成骨過程中腓腸肌的適應(yīng)性改建分析》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、天津醫(yī)科人學(xué)碩士學(xué)位論文limb，nodeformityunion．2．Distractingtibiainducestheinjuryofgastrocnemius，butgastrocnemiuscallrepairbyitselfduringconsolidationperiod．111estructuralchangeswereobservedbylightmicroscopeincludingthemusclefibres’degradation，muscleplasmacrumblingdegeneration，musclenucleii
2、nternalization；somechangeswereobservedbytransmissionelectronmicroscopyincludingmyofibrilsatrophyanddisorderedarrange,swelledmitochondrion，musclenucleiinternalization．Duringtheconsolidationperiod，musclerepairedgraduallyitself,untilthelatestageofconsolidationperiod(8weeks)，thestr
3、uctureofgastrocnemiusreturnsnormalstructure．3．TheexpressionofIGF—1weredifferentduringtheprogressoftibiadistractionosteogenesis．neIGF一1expressionofcontrolgroupwasnegative；atconsolidation0daytheexpressionofIGF-lWasstrongpositive；atconsolidation7dayswasalsoactive,butlessthanthegro
4、upofconsolidation0day；fromtheconsolidation14days，theexpressionofIGF-lbegandecline；attheconsolidation14days，theexpressionofIGF-1furtherdecline,attheconsolidation56days．theexpressionofIGF-1wasthesameasthecontrolgroup．Conclusion：1．Rabbitisanoptimaloptionforlimblengtheninganimalmod
5、el．X—rayisatraditionalexaminationwaytodetectthenewboneformationindifferentlengtheningstages．Therabbitlimblengtheningmodelwereestablishedsuccessfully．ThismodelcanbeappliedtothefollowingexperimentsentirelyandCanacquiredtheprecisedata．2．Duringslowlimblengthening，thesubclinicalperi
6、pheralmuscleinjuryisreversible．nenaturalrepairoftheinjuriedmusclehasbegunassoonasthemusclewasinjuried．3．Duringtheprocessoftibiadistractionosteogenesis，theruleofexpressionchangesofIGF-1Wasinaccordancewiththeruleofstructurechangesofgastrocnemius．ThisresultmaycuesthatIGF．1mediates
7、thefunctionalremodelingofgastrocnemlus．一．
8、一Keywords：distractionosteogenesisrabbittibiagastrocnemiusultrastructureIGF．11．1．3動(dòng)物模型及分組?????????????????·???··41．1．4動(dòng)物模型的制備方法???????????????????41．1．5X線檢查??????????????????·?????··71．1．6標(biāo)本制備和組織學(xué)檢查??????????????????71．2結(jié)果???????????????
9、?????????????81．2．1X線檢查結(jié)果??????????????????????81．2．2大
