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《益氣活血、通絡(luò)消癥法治療pfsgs氣虛血瘀證的臨床研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、提要目的：在西醫(yī)治療基礎(chǔ)上，予益氣通絡(luò)飲為主方隨癥加減，治療原發(fā)性局灶節(jié)段性腎小球硬化（pFSGS），觀察其臨床療效，探討中西醫(yī)結(jié)合治療本病的優(yōu)勢(shì)和可行性，為進(jìn)一步改良及推廣配方打下基礎(chǔ)。方法：本研究收集pFSGS患者(經(jīng)腎活檢病理診斷為局灶節(jié)段性腎小球硬化，排除繼發(fā)性疾病。)符合中醫(yī)氣虛血瘀型患者60例，并隨機(jī)分為2組，試驗(yàn)組、對(duì)照組各30例。對(duì)照組予以控制血壓、抗凝、降蛋白尿等西醫(yī)基礎(chǔ)治療，試驗(yàn)組在西醫(yī)基礎(chǔ)治療上加用益氣通絡(luò)飲并隨癥加減，療程為二個(gè)月。觀察兩組臨床癥狀、體征及實(shí)驗(yàn)室檢查指標(biāo)的變化情況。結(jié)果：pFSGS
2、氣虛血瘀型中醫(yī)量化評(píng)分：試驗(yàn)組總有效率96.67%，對(duì)照組總有效率56.66，兩組比較有顯著統(tǒng)計(jì)學(xué)意義（p＜0.01）。試驗(yàn)組用藥后積分與用藥前積分相比具有顯著的統(tǒng)計(jì)學(xué)意義（p＜0.01）。臨床緩解率實(shí)驗(yàn)組總有效率86.67％，對(duì)照組總有效率80.00％，兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0．05)：兩組治療前后血脂、血漿白蛋白、24h尿蛋白定量比較差異均有明顯統(tǒng)計(jì)學(xué)意義(P<0.01)，且兩組組治療后比較差異均有明顯統(tǒng)計(jì)學(xué)意義(P<0．01)。結(jié)論：益氣通絡(luò)飲隨證加減配合西醫(yī)基礎(chǔ)治療pFSGS氣虛血瘀型，能顯著改善患者身倦
3、乏力、顏面或肢體浮腫、腰痛固定或刺痛等臨床表現(xiàn)，降低24h尿蛋白定量，升高血漿白蛋白，糾正脂質(zhì)代謝紊亂，從而顯示出中西醫(yī)結(jié)合治療本病的優(yōu)勢(shì)。關(guān)鍵詞益氣通絡(luò)飲；pFSGS；氣虛血瘀型；ClinicalStudyonPrimaryFocalSegmentalGlomerulosclerosis(FSGS)ofbloodstasisduetoqideficiencywithmethodsoftonifyingqiandinvigoratingthecirculationofblood,dredgingcollateralsan
4、ddissipatingagglomerateSpecial:InternalMedicineofIntegratedTCMandWesternMedicineStudent:LiuYanTutor:Prof.GuoZhaoanAbstractObjective:Toinvestigatetheeffectofyi-qi-tong-luo-yin（YQTLY）treatingpFSGSofbloodstasisduetoqideficiencyonthebasisofwesternmedicinetreatment.To
5、exploretheadvantagesandfeasibilityofcombiningtraditionalChineseandwesternmedicinetreatingpFSGSandlaythefoundationforfurtherimprovement.Methods:60patientswithpFSGSofbloodstasisduetoqideficiencywererandomlydividedinto2groups,experimentalgroupandcontrolgroup,eachgro
6、upwas30cases.Patientsincontrolgroupweretreatedbyroutinetherapy,whilepatientsinexperimentalgroupweretreatedbycombinationofYQTLYandroutinetherapy.Thecourseoftreatmentis2months.Thecurativeeffectandtherelatedindexesweredeterminedbeforeandaftertreatment,thechangeofpat
7、ients'clinicalsymptomswasrecorded.Results:Thetotaleffectiverateintheexperimentalgroup(96.67%)washigherthanthatinthecontrolgroup(56.66%,p<0.01).Itissignificantlydifferentbetweenthescoresofpro-treatmentandpost-treatment(p<0.01)intheexperimentalgroup.Thereisnosignif
8、icantdifferenceintheremissionofpFSGSbetweenthecontrolgroupandtheexperimentalgroup.Thereweresignificantdifferencebetweentwogroupson24hurineprotein,ALB,TCHandTGa
