資源描述：
《聚醚醚酮基復(fù)合材料表面成骨多肽功能化修飾的分析》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、重慶醫(yī)科大學(xué)碩士研究生學(xué)位論文提高了PEEK基復(fù)合材料的細(xì)胞相容性和成骨誘導(dǎo)活性，且能促進植入體在體內(nèi)的骨整合功能，是一種可靠、易行且安全的材料表面修飾方法。關(guān)鍵詞：聚醚醚酮基復(fù)合材料，成骨多肽，聚多巴胺，功能化修飾4萬方數(shù)據(jù)重慶醫(yī)科大學(xué)碩士研究生學(xué)位論文THERESEARCHOFOSTEOGENICMODIFICATIONWITHBFP-1PEPTIDEVIAPOLYDOBAMINEONSURFACEOFPOLYETHERETHERKETONENANOCOMPOSITESABSTRACTAfterimplanted,implantswilldirectl
2、yinteractwiththesurroundingbonetissuesthroughtheirsurface.Thesurfacepropertiesofimplantscaninfluencethebonecelladhesion,proliferationanddifferentiation;lastlydeterminethequalityofboneintegration.Therefore,it’sanimportantfactorforthesuccessofimplantoperation.Forimprovingthesuccessr
3、ateofclinicalimplant,theimplantsshouldhavegoodbiocompatibilityanddecentmechanicalproperties;alsoneedtohaveosteogenicactivitytoformgoodboneintegrationwiththesurroundingbonetissue.OurresearchgrouppreparedofPEEK/CF/n-HAcompositematerialsbyaddingbioactiveHAandhighstrengthofCF.Although
4、itsmorematchesonthemechanicalpropertiesofthebonetissue,canavoidstressconcentrationthatcouldleadtoboneresorption,implantslooseetc.ButthePEEK/CF/n-HAcompositelackthegoodbiocompatibilityandgoodboneintegration.Therefore,itisnecessarytoseekabettermethodforsurfacemodification.Usingprote
5、inandpeptidefragmentsasabiologicalactivityofbiological5萬方數(shù)據(jù)重慶醫(yī)科大學(xué)碩士研究生學(xué)位論文materialiscurrentlyoneofthehotspotintheresearchoftissueengineering.Researchprovesthatbioactiveproteinsandpolypeptides(suchascollagenandfibronectin,RGDpeptidesorbonemorphogeneticproteins,etc.)canpromotetheact
6、ivityofcells,adhesion,proliferationanddifferentiation.Proteinshavesomeproblemssuchasimmunogenicityandeasytodecompose.However,peptidefragmentscansyntheticmoreeasily,noimmunogenicity,andalsohasthefunctionoftheactivityofbiologicalmacromolecules,ofRGDdomainstructurethatinterceptedfrom
7、proteinshadbeenreportedthathasthefunctionofpromotingcelladhesion.intheresearchofthebonemorphogeneticproteins(BMPs),HyungKeunKim,etcextractedapolypeptidefromthematuresectionstructureofBMP7,namedBFP1.Afterthedetectionofinvivoandinvitro,foundtheosteogenicactivityofBFP1issuperiortoBMP
8、-7.Inordertoobtainabetterosteogen
