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1、萬方數(shù)據(jù)·186·旦醫(yī)勝瘦堂盤查!Q!!生!旦箜!!鲞筮!翅.』!墮Q!型:墮!嬰!墊!!:!!!:!!:盟!:!‘forrepressionby”EZH2itiprostatecancer.Oncogene,2010,29(39):5370-5380.[28]SasakiM,YamaguchiJ,ItatsuK,eta1.Over—expressionofpoly.combgroupproteinEZH2relatestodecieasedexpressionofp16INK4aincholangiocarcinogenesisinhepatolithiasis.JPathol,200
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4、32]DimriM,BommiPV,SahasrabuddheAA,eta1.Dietaryomega一3polyunsaturatedfattyacidssuppressexpressionofEZH2inbreastcancercells.Carcinogenesis,2010,31(3):489-495,[33]HuangWY,YangPM,ChangYF,eta1.MethotrexateinducesapoptosisthroughP53/p2l-dependentpathwayandincreasesE—cad—herinexpressionthroughdownregula
5、tionofHDAC/EZH2.BiochemPharmacol,2011,81(4):510-517.(收稿日期:2011-09-30修回13期:2011—11-01)腫瘤的基因靶向檢測。和治療鄭亞冰王林常曉天【摘要】隨著分子靶向藥物和個體化治療的研發(fā)和臨床使用,腫瘤的基因靶向檢測和治療已成為腫瘤治療的熱點。尤其是針對表皮生長因子受體(EGFR)信號通路相關(guān)基因、DNA復制相關(guān)基因、紡錘體形成相關(guān)基因、細胞代謝過程相關(guān)基因等分子靶向檢測和治療,靶點分子的基因多態(tài)性決定了靶向藥物治療的有效性。【關(guān)鍵詞】腫瘤;分子診斷技術(shù);抗腫瘤藥Genetargetingdiagnosisandtrea
6、tmentincancerZHENGYa—bing,WANGLin,CHANGXiao—tian.Shah—dongMedicinalBiotechnologyCenter,ShandongAcademyofMedicalScience,Jinan250062,China【Abstract】Withthedevelopmentandclinicaluseofthemoleculartargeteddrugsandindividualizedtreatment,cancerresearchhasbeenfocusedongenetargetingdiagnosisandtreatment.
7、Especiallyfortheepi—dermalgrowthfactorreceptor(EGFR)signalingpathway—relatedgenes,DNAreplication—relatedgenes,spindleapparatusformat—relatedgenes,cellmetabolism—relatedgenesandothermoleculartargeteddetectionandtreat—me