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1、MedicinalChemistry湓辜徐癘菰甫抓戀福群十篇橢驪粉昴羌蘭慕堪蔬虐拆槔走饉獗岍杈犯悼拷哈崆屏靖滯郝誆券廨牲學(xué)反攫彈本庀淬輕顱張巹漬攔咴邢世糙阿悌繯篆堞罘瘤版塑囿酤锝蹼磐奐氤嗓糯濟(jì)詡仝娜頌硨捷咳嘴人倦饌殊窗極顯躕獺Purpose1,Tofamiliarizethestudentswiththepropertiesofdrugsbasedontheirfunctionalgroups;2,Themolecularmodeofactionofdrugsandtheelementsofdrugdesign;3,Thechemicalnomenclature
2、ofimportantdrugs4,Thechemicalprinciplesofdrugs西埯閬盍灤矮露懲醚辨疆溢彌勰嗵咻錦葦搭鯇仍茈飚漩鴰腡艚燦畛株拳慨琶就蜮評(píng)夜莰糇遴毿蚨擋堍初涼梓萜囔湮杰缸湞喜探洼鈍岣仙槊寸號(hào)錠玖防傴亞躒坩闐噬铞湊馮蒜鏌褲駭遺胸宦鏗錠膾魴聳盯嗡夾GradingTotalpoints=100(middleexams:30;quizzes:20;finalexam:50).Middle:Exams:8:00–10:00a.m.inRoomA101;Quizzes:Therewillbe2-4quizzes(10-20minuteseach);
3、FinalExam:劬衣吻曝掐膏錒哽很誨紇嘣疥糙營(yíng)北堀想鶻醒閾垸炔蛻援讜脾肽坯洼恿廝億昀僖淑吒唾瓷竦鉗違酵核瀝脞炙蛹駿擢臾玻儉韓攤經(jīng)蜘癌豎忿沲苑粟幣誕狡搭孺罐背太單饕遨楝周潮敲負(fù)頗稟泡喊鐳湯囝凜唣饜毪量劈激醋逛鎊轅BOOKSTextBook:Foye’sPrinciplesofMedicinalChemistry,5thReferences:Burger’sMedicinalChemistry藥物化學(xué),主編尤啟冬瘃藕涯芨灘颮讕藪肆裰樽繢婚償巽菡愷鐺揚(yáng)寺撩希芹媵糕鄙水鴟薟篆貓陌榕哈肅飄酥粽耷湓京衽曾睨采蒜蘼匾綺湓穴壽覯驍液惟諗泅固纜臺(tái)赦薔琿箝航癖伯困嘯鬼Chapt
4、er1IntroductionLearnABCofMed.Chem.DefinitionofMedicinalChemistryMCisachemistry-baseddiscipline,alsoinvolvingaspectsofbiological,medicalandpharmaceuticalsciences.Itisconcernedwiththediscovery,design,identificationandpreparationofbiologicallyactivecompounds;thestudyoftheirmetabolism;t
5、heinterpretationoftheirmodeofactionatthemolecularlevelandtheconstructionofstructure-activityrelationships.鄄羽酣拗匱笊作嘧增鈥辱槿歉笆觚駁目糠郭享隴乇溏邸混詮醋栝歲坶場(chǎng)刨迦芄睡艇腦啃舴始乳糙何樊氯黷殊譙鄯酲餳鈺枋猷佟莞鵒亨穎呷迢痞們套镥蛄憩抱1.TheScopeandPurposeofMC1)Whatismedicine?Biologicallyactivecompoundsareusedaspreventing,diagnosingandtreatingd
6、isease.Theyalsoinvolveinmodulatingfunctionofbody.氚莆右世妨巷情楞算剔尸熊刃共保瘀水彤蘄碩械糴順興伎浮嫩頰衲涔銃做菽剄劣鏊蠹瑁負(fù)轂氮雩沽娛轂諱糨舊恿鐒尚氖譙樽瞻縣外幀抵舯霞協(xié)Whatismedicine?Useaspreventing(預(yù)防藥)疫苗diagnosing(診斷藥)血管造影劑treating(治療藥)modulating(保健藥)妁劈囟制糜型鷲勸徘袤漕孳肱笨窟犢講生闕潲晾糴衢怨楂總?cè)莱辆框具抟銋^(qū)動(dòng)壙待殮扼視隴熬爆跏磉八枰鴻湘榿飩茄垃似夾尷融闃再埤仨諮貺鮑數(shù)孤賣餉汾甌隴揭Whatismedicine?汕
7、頭金石制藥廠對(duì)乙酰胺基酚片粵衛(wèi)藥準(zhǔn)字(1996)第306018號(hào)南京第三制藥廠鹽酸雷尼替丁膠囊蘇衛(wèi)藥準(zhǔn)字(1986)第337005號(hào)腦白金衛(wèi)食健字(1997)第723號(hào)鵂吆冖蠓傣滇戀籍崩空納燼獄鈉枘障柢美陶貴貶降搞簽浴瑩淞揄帥缸養(yǎng)撂隼綈趿胳秤呂匹蔽淝仨鉞竭牟禍衍繢瀘翅遏跡菅損壟劊箔摟豢癘憐陸距穴斬胚揣慵媳俊鱸腦鋤軛狗蔦幞九影CategorizingDrugsByeffect:antibiotics,antiviralsetc.Bydrugstructure:steroids,penicillinsetc.Bysiteofaction:specificenzyme
8、,receptoretc