抗纖方對肝纖維化大鼠肝組織金屬蛋白酶及其抑制因子表達的影響

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1、湖北中醫(yī)學院碩士學位論文抗纖方對肝纖維化大鼠肝組織金屬蛋白酶及其抑制因子表達的影響姓名：張愛忠申請學位級別：碩士專業(yè)：中醫(yī)臨床基礎指導教師：伍定邦2003.6.1．塑些生鑒蘭壁矍主!些絲塞——ABSTl淑CTObjective：ToreproducehepaticfibrosismodelofratsandobservetheeffectofKangXianRuanGanChongJi(KXRGCJ)intreatmentofdifferentgropeofthoserats，especiallytoobservetheeffectonmat

2、rixmetalloproteinase一1(醚挺P—t)、tissueinhibitorsofmetat—loproteinase一1(TI酣P—I)mRNAexpression，Soastostudythemechan—iSillofKXrGCJNethods：Experimentoftreatinghepaticfibrosis：Fromthebeginningtomakemodels，90wistarratswererandomlydividedinto6groups：normalcontrolgrope(10)、ultrastruc

3、turegrope(16)、colchicinesgrope(16)、andECM(KXrGCJ)gropes(16respectively)。Exceptthenormalgrope，alloftheothers(themodelgropes)wereinducedtohepaticfibrosisbyCOl·andadministeredrespectivelywithwateratthedoseof2ml／1009／d(theultrastructuregrope)、colchicinesatthedoseoflmg／lOOg／d(th

4、ecolchicinesgrope)、ECMatthedosesof0．69、1．29、2．49／lOOg／d(thelow、middle、highdoseECMgrope)。Attheendoftheeii出thweek，alloftheremnantratswerekilled，Somepartsof1iverweretakenwhichwouldbeusedintheexperimenteResult：(1)HP一1expression．．Comparewiththeultrastructuregrope，the1eveloftheno

5、rmalgropeiSmodestlylower，butthedifferenceiSnotmarked(P>O．05)．thelevelsofthegropestreatedwithmedicinearemarkedlyhigher(PO．05)．thelevelSofthemiddleandhighdose袋瀑gro

6、pesaremarkedlyincreased(P<&05)：Comparewiththemiddledosegrope，thelevelofthelowdoseECMiSmarkedlylower(PO．05)．(DTIMP一1expression：themodelgropesaresignificantlyhigherthanthatofthenormalgrope(P(0。0

7、1)；Comparewiththeuttrastructuregrope，thelevelsofthegropestreatedwithmedicinearemarkedlylower(P>O．05)：Comparewiththecolchicinesgrope，thelevelofthelowdoseECMgropeismodestlylower。butthediffer-enceiSnotmarked(P>O．05)，thelevelSofthemiddleandhighdoseECMgropesaremarkedlydecreased(

8、K袋05)tComparewiththemiddle-2-潮囂巾醫(yī)學院磺士畢監(jiān)論義dosegrope，thelevelofthelowdoseECMismarked