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1、FEATURE甲磺酸倍他司汀治療內(nèi)耳缺血相關(guān)性眩暈的療效研究TheeffectofbetahistinemesylateasatreatmenttovertigoinducedbyinnerearischemiaTheeffectofbetahistinemesylateasatreatmenttovertigoinducedbyinnerearischemia吳子明,張素珍,劉興健,陳艾婷,冀飛,楊偉炎,韓東一【摘要】目的通過觀察良性陣發(fā)性位置性眩暈(benignvertigoandtostudythecausalrelationsh
2、ipsofdosage.positionalparoxysmalvertigo,BPPV)、后循環(huán)缺血MethodNinetycasesofBPPV,PCIandMVwith30casefor(posteriorcirculationischemia,PCI)、偏頭痛性眩暈eachdiseasewererecruitedfortheexperiment.Patientswith(migrainousvertigo,MV)、青少年良性眩暈在服用不同eachdiseasewerethendividedinto2groups,15casein
3、劑量的甲磺酸倍他司汀后的臨床表現(xiàn),了解甲磺酸倍他司汀eachgroup.Group1wastreatedwithbetahistinemesylate治療內(nèi)耳缺血性眩暈的療效。方法BPPV、PCI、MV各306mg3/d,Group2withbetahistinemesylate12mg3/d.例,分成2組。組一:甲磺酸倍他司汀6mg,3/日;組二:Twenty-?vepatientswithteenagerbenignparoxysmalvertigo甲磺酸倍他司汀12mg,3/日,治療均為期1個月。觀察量-效weregivenbet
4、ahistinemesylate,6mg3/dfordurationof1關(guān)系。青少年良性陣發(fā)性眩暈25例不分組,甲磺酸倍他司汀month.Highstimulatingrateofauditorybrainstemresponse6mg3/日,服藥治療1月。分別觀察治療前后高刺激聽性腦干(ABR)anddizzinesshandicapinventory(DHI)were測聽(auditorybrainstemresponse,ABR)和眩暈殘障程度administeredandcomparedbeforeandafteradmini
5、stration(dizzinesshandicapinventory,DHI)的變化。結(jié)果四類ofbetahistinemesylate.ResultsThesymptomsofthe眩暈治療后癥狀減輕,高刺激ABR和DHI均有改善,而眼動異patientswerereduced.BothhighstimulatingrateABRand常變化不明顯。連續(xù)用藥1個月后,BPPV、PCI、MV三類患DHIwereimproved,whereastheabnormalityofocular者12mg,3/日方案療效優(yōu)于6mg,3/日方案。
6、青少年良性眩motionremained.Onemonthaftertreatment,thetherapeutic暈6mg,3/日方案也獲得滿意療效。結(jié)論甲磺酸倍他司汀對protocolof12mg3/dwasbetterthanthatof6mg3/d.The良性陣發(fā)性位置性眩暈、后循環(huán)缺血、偏頭痛性眩暈和青少年protocolof6mg3/dfor1monthalsoindicatedsatisfactory良性眩暈等與內(nèi)耳低灌注有關(guān)的眩暈有較好的治療作用,并表treatmentresultsonteenagerbenignpar
7、oxysmalvertigo.現(xiàn)出量效關(guān)系,12mg,3/日方案療效優(yōu)于6mg,3/日方案。ConclusionThecurativeeffectofbetahistinemesylateon【關(guān)鍵詞】甲磺酸倍他司??;內(nèi)耳;缺血;眩暈BPPV,PCI,MVandteenagerbenignparoxysmalvertigowas【Abstract】ObjectiveToobservetheeffectofbetahistinesatisfactory.Thetherapeuticprotocolof12mg3/dwasmoremesyl
8、ateasatreatmenttobenignpositionalparoxysmaleffectivethanthatof6mg3/d.vertigo(BPPV),posteriorcirculation