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《Genomic adaptation of ethanologenic yeast to biomass conversion inhibitors英文資料》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、ApplMicrobiolBiotechnol(2006)73:27–36DOI10.1007/s00253-006-0567-3MINI-REVIEWGenomicadaptationofethanologenicyeasttobiomassconversioninhibitorsZ.LewisLiuReceived:10May2006/Revised:3July2006/Accepted:9July2006/Publishedonline:7October2006#Springer-Verlag2006AbstractOnemajorbarriertotheeconomic
2、conversionofKeywords5-Hydroxymethylfurfural.Biotransformation.biomasstoethanolisinhibitorycompoundsgeneratedFurfural.Genomicexpression.Insitudetoxificationduringbiomasspretreatmentusingdiluteacidhydrolysis.Majorinhibitorssuchasfurfuraland5-hydroxymethylfur-fural(HMF)inhibityeastgrowthandsubs
3、equentfermen-Introductiontation.TheethanologenicyeastSaccharomycescerevisiaedemonstratedadose-dependantinhibitionbytheinhibitorsAsinterestinalternativeenergysourcesrises,theconceptandhasthepotentialtotransformfurfuralandHMFintoofagricultureasanenergyproducerhasbecomeincreas-lesstoxiccompound
4、soffurfurylalcoholand2,5-bis-inglyattractive(Outlawetal.2005).Renewablebiomass,hydroxymethylfuran(alsotermedasfuran-2,5-dimethanolincludinglignocellulosicmaterialsandagriculturalresi-(FDM)),respectively.Forasustainableandcost-competi-dues,arelow-costmaterialsforbioethanolproductiontivebiomas
5、s-to-ethanolindustry,itisimportanttodevelop(BothastandSaha1997;Whealsetal.1999;Zaldivaretmoretolerantyeaststrainsthatcan,insitu,detoxifytheal.2001).Onemajorbarrierofbiomassconversiontoinhibitorsandproduceethanol.Thisstudysummarizesethanolisinhibitorycompoundsgeneratedduringbiomasscurrentknow
6、ledgeandourunderstandingoftheinhibitorspretreatmentusingdiluteacidhydrolysis,whichinterferefurfuralandHMFanddiscussesmetabolicconversionwithmicrobialgrowthandsubsequentfermentation.Furfu-pathwaysoftheinhibitorsandtheyeastgenomicexpres-raland5-hydroxymethylfurfural(HMF)aremajorinhib-sionrespo
7、nsetoinhibitorstress.Unlikelaboratorystrains,itorscommonlyrecognizedfromthebiomasspretreatment.geneexpressionresponseoftheethanologenicyeasttoThegeneticmechanismsinvolvedinstresstolerance,suchfurfuralandHMFwasnottransient,butacontinuedasthosecaused
