資源描述：
《免疫球蛋白的結(jié)構(gòu)與功能的關(guān)系》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫(kù)。
1、ImmunoglobulinStructure-FunctionRelationship免疫球蛋白的結(jié)構(gòu)與功能的關(guān)系SignallingantigenreceptorsonBcells-bifunctionalantigen-bindingsecretedmolecules（B細(xì)胞表面受體和分泌的抗體）Structuralconservationandinfinitevariability-domainstructure（結(jié)構(gòu)上不僅保守而且無(wú)限可變的）.TheImmunoglobulinGeneSuperfamily（免疫球蛋白的超家族）Theimmunoglobulinfold（免疫球
2、蛋白的折疊）Frameworkandcomplementaritydeterminingregions-hypervariableloops（框架結(jié)構(gòu)和可變區(qū)）Modesofinteractionswithantigens（與抗原相互作用的模型）Effectormechanismsandisotype–roleoftheFc.（Fc區(qū)的作用）MultimericantibodiesandmultimerisationCharacteristicsandpropertiesofeachIgisotypeIgreceptorsandtheirfunctionsImmunoglobulinSt
3、ructure-FunctionRelationshipCellsurfaceantigenreceptoronBcellsB細(xì)胞表面受體和分泌的抗體AllowsBcellstosensetheirantigenicenvironmentConnectsextracellularspacewithintracellularsignallingmachinerySecretedantibody（抗體）Neutralisation（中和作用）Arming/recruitingeffectorcells（激活或者誘導(dǎo)功能細(xì)胞）Complementfixation（幫助機(jī)體對(duì)抗原的清除）Immu
4、noglobulinStructure-FunctionRelationshipImmunoglobulinsareBifunctionalProteinsImmunoglobulinsmustinteractwithasmallnumberofspecialisedmolecules-（免疫球蛋白必須與特殊分子相互作用）Fcreceptorsoncells（細(xì)胞表面的Fc受體）Complementproteins（輔助蛋白）Intracellularcellsignallingmolecules（細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)分子）whilstsimultaneouslyrecognisinganin
5、finitearrayofantigenicdeterminants.（同時(shí)能夠識(shí)別無(wú)限抗原族）StructuralconservationandacapacityforinfinitevariabilityinasinglemoleculeisprovidedbyaDOMAINstructure.（結(jié)構(gòu)上不僅保守而且無(wú)限可變的-抗體結(jié)構(gòu)域）Igdomainsarederivedfromasingleancestralgenethathasduplicated,diversifiedandbeenmodifiedtoendowanassortmentoffunctionalqualiti
6、esonacommonbasicstructure（Ig結(jié)構(gòu)域源于一個(gè)原始基因，復(fù)制，多元化，修飾等）Igdomainsarenotrestrictedtoimmunoglobulins（Ig結(jié)構(gòu)域不僅僅局限于免疫球蛋白）.ThemoststrikingcharacteristicoftheIgdomainisadisulphidebond-linkedstructureof110aminoacidslong（Ig結(jié)構(gòu)域最明顯的特點(diǎn)是其雙硫鍵，連接了110個(gè)氨基酸）.ImmunoglobulindomainsThegenesencodingIgdomainsarenotrestricte
7、dtoIggenes.Althoughfirstdiscoveredinimmunoglobulins,theyarefoundinasuperfamilyofrelatedgenes,particularlythoseencodingproteinscrucialtocell-cellinteractionsandmolecularrecognitionsystems.IgSFmoleculesarefoundinmostcell
