Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates

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1、SupplementalMaterialcanbefoundat:http://www.jbc.org/content/suppl/2010/09/16/M110.127829.DC1.htmlTHEJOURNALOFBIOLOGICALCHEMISTRYVOL.285,NO.47,pp.36958–36968,November19,2010?2010byTheAmericanSocietyforBiochemistryandMolecularBiology,Inc.PrintedintheU.

2、S.A.OverexpressionofHumanApolipoproteinA-IPreservesCognitiveFunctionandAttenuatesNeuroinflammationandCerebralAmyloidAngiopathyinaMouseModelofAlzheimerDisease*□SReceivedforpublication,March26,2010,andinrevisedform,September13,2010Published,JBCPapersin

3、Press,September16,2010,DOI10.1074/jbc.M110.127829?§????
??TerryL.Lewis,DongfengCao,HailinLu,RobertA.Mans,YanRuSu**,LisaJungbauer,MacRaeF.Linton**,???§?
1SergioFazio**,MaryJoLaDu,andLingLi?§
FromtheDepartmentsofMedicine,Pathology,andNeurobiology,Unive

4、rsityofAlabamaatBirmingham,?Birmingham,Alabama35294,theDepartmentofExperimentalandClinicalPharmacology,UniversityofMinnesota,Minneapolis,Minnesota55455,the**DepartmentofMedicine,VanderbiltUniversityMedicalCenter,Nashville,Tennessee37232,??andtheDepar

5、tmentofAnatomyandCellBiology,UniversityofIllinois,Chicago,Illinois60612TodatethereisnoeffectivetherapyforAlzheimerdisease2Alzheimerdisease(AD)iscurrentlyestimatedtoaffectover(AD).Highlevelsofcirculatinghighdensitylipoprotein(HDL)5millionpeopleintheUn

6、itedStatesalone.Eachday,
1,200Downloadedfromanditsmainprotein,apolipoproteinA-I(apoA-I),reducethenewcasesofADdevelop,whichtranslatesto450,000newcasesriskofcardiovasculardisease.Clinicalstudiesshowthatplasmaeachyear.Duetoouragingpopulation,itisexpecte

7、dthattheHDLcholesterolandapoA-IlevelsarelowinpatientswithAD.prevalenceofthediseasewilldoubleinthenext40years(1).ToinvestigateifincreasingplasmaapoA-I/HDLlevelsamelio-ThereisnoknowncureforAD,andonlyafewtreatmentsareratesAD-likememorydeficitsandamyloid

8、-
(A
)deposition,availablethatslowtheprogressionofsymptoms.Thecurrentwegeneratedalineoftripletransgenic(Tg)miceoverexpressingmantrainthefieldofADresearchisthatlossofneurons,www.jbc.orgmutantformsofamyloid-
precursorprotein(APP)andprese-increaseininfl