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1、Langmuir2005,21,1305-13131305PhysicochemicalandInterfacialInvestigationofLipid/PolymerParticleAssembliesAnne-LiseTroutier,ThierryDelair,ChristianPichot,andCatherineLadavieáre*UMR2714CNRS/bioMe?rieux,SysteámesMacromole?culairesetPhysiopathologieHumaine,ENSL,46,alle?ed?Italie,69364LyonCedex07
2、,FranceReceivedSeptember20,2004.InFinalForm:November2,2004Amodelstudywasinvestigatedtodevelopcolloidalsupramolecularassembliesconsistingofparticlescoatedwithlipidlayers.Theinteractionsbetweenmonodispersesulfate-chargedpoly(styrene)submicrometerparticlesandzwitterionic/cationiclipidvesiclesc
3、omposedof1,2-dipalmitoyl-sn-glycero-3-phosphocholineand1,2-dipalmitoyl-3-trimethylammoniumpropanewereconsidered.Theinfluenceofrelevantexperimentalparametersonthefinalassociationswasexaminedbyquasi-elasticlightscatteringtopointoutsomenewphenomenaoccurringinthesecolloidalsystems.Themajorroleo
4、felectrostaticinteractionsasdrivingforcestocontroltheorganizationbetweencationiclipidsandoppositelychargedpoly(styrene)particleswasclearlyevident,whereasthisinfluencewaslesspronouncedwhenconsideringthezwitterioniclipids.Thecharacterizationoftheseoriginalcomplexassemblieswascompletedbyathoro
5、ughstudyofthesurfacemodification.Thecombinationofzetapotentialmeasurements,X-rayphotoelectronspectroscopyanalyses,andmicroscopyobservationsprovedthattheenvisionedmodelcanreallycorrespondtopolymerparticlessurroundedbylipids.Introductiontions,wereusedtodeterminemolecularorder,9,10lateraldiffu
6、sion,3,5,7-8,10orphasetransitiontemperature2,6-7ofThedepositionoflipidsinlayersontosphericalcolloidssupportedlipids,aswellaslipid/proteininteractions.4leadstooriginalassemblies(i.e.,aparticlecorecoatedGlassmicrospherescoatedwithphospholipidlayersaswithlipids)thatareofinterestinbiotechnology
7、andasmembranemodelswerealsopreparedtoevaluatethedrug,antigen,orgenedeliverysystems.Indeed,thebindingspecificityofenzymesoncellsurfaces11ortoobtainedcompositestructuresassociatetheadvantagesscrutinizetheparticularlipid/antibodybinding.12,13Aofparticlesand
