資源描述：
《Regulation of megakaryocyte maturation and platelet formation巨核細(xì)胞成熟和血小板形成的調(diào)節(jié)》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、JournalofThrombosisandHaemostasis,7(Suppl.1):227–234DOI:10.1111/j.1538-7836.2009.03398.xINVITEDREVIEWRegulationofmegakaryocytematurationandplateletformationD.BLUTEAU,*àL.LORDIER,*àA.DISTEFANO,*àY.CHANG,*àH.RASLOVA,*àN.DEBILI*àandW.VAINCHENKER*à*I
2、NSERM,U790,39rueCamilleDesmoulins,Villejuif;InstitutGustaveRoussy,39rueCamilleDesmoulins,Villejuif;andàUniversite′ParisXI,39rueCamilleDesmoulins,Villejuif,FranceTocitethisarticle:BluteauD,LordierL,DiStefanoA,ChangY,RaslovaH,DebiliN,VainchenkerW.Regulat
3、ionofmegakaryocytematurationandplateletformation.JThrombHaemost2009;7(Suppl.1):227–34.MKprogenitorshavealsobeendescribed.Terminaldifferen-tiationbeginswiththesynthesisofspeci?cplateletproteinsand11Summary.Eachdayineveryhuman,approximately1·10initiationo
4、ftheendomitoticprocess.plateletsareproducedbythecytoplasmicfragmentationofDuringmaturation,theMKcytoplasmbecomesverymegakaryocytes(MK),theirmarrowprecursorcells.Plateletsspecializedwiththedevelopmentofacomplexsystemofarethepredominatingfactorintheproces
5、sofhemostasisandmembranes,calledthedemarcationmembranesystem,andthrombosis.Recentstudieshaveshownthatplateletsalsoplayadifferenttypesofgranulesincludinglysosomes,densegranuleshithertounsuspectedroleinseveralotherprocessessuchasanda-granules.Proteinscont
6、ainedinthea-granules(special-in?ammation,innateimmunity,neoangiogenesisandtumorizedsecretorygranules)canbesynthesizedorendocytosed.metastasis.ThelatephasesofMKdi?erentiationidenti?edbySynthesizedproteins,suchasPF4orVWF,aredetectedearlypolyploidization,m
7、aturationandorganizedfragmentationofindifferentiationintheendoplasmicreticulumandtheGolgiinthecytoplasmleadingtothereleaseofplateletsintheblood2NcellsexpressingCD41(GPIIb/IIIa)andCD42(GPIb).streamrepresentauniquemodelofdi?erentiation.TheTheirexpressioni
8、ncreasesandtheylocalizeintoa-granules.molecularandcellularmechanismsregulatingplateletbiogen-Someotherproteinsbindtomembranereceptors,like?brin-esisarebetterunderstoodandmayexplainseveralplateletogentoGPIIb/IIIa,areendocytosedand
