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《臨床醫(yī)學(xué)畢業(yè)論文慢性乙型肝炎患者血清afp動(dòng)態(tài)監(jiān)測(cè)臨床意義》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。
1、XX大學(xué)畢業(yè)論文慢性乙型肝炎患者血清AFP動(dòng)態(tài)監(jiān)測(cè)臨床意義姓名：2014年6月25日【摘耍】目的：動(dòng)態(tài)監(jiān)測(cè)慢性乙型肝炎患者血清甲胎蛋白(AFP)變化及肝功能指標(biāo)，探討慢性乙型肝炎各模式與AFP定量變化及肝功能改變的關(guān)系，高度警惕肝癌的發(fā)生。方法：對(duì)189例慢性乙型肝炎患者同時(shí)用ELISA法進(jìn)行乙型肝炎五項(xiàng)血清學(xué)標(biāo)志物、用RIA法進(jìn)行AFP檢測(cè)和谷丙轉(zhuǎn)氨IW(ALT)、谷草轉(zhuǎn)氨酶(AST)、谷胺酰轉(zhuǎn)肽酶(GGT)和堿性磷酸酶(ALP)的水平檢測(cè)。AFP升高者分別作B超、CT檢查，排除肝癌后每2個(gè)月復(fù)查1次AFP、肝功、B超，連續(xù)進(jìn)行
2、2a~5a追蹤隨訪。結(jié)杲：189例中146例AFP不同程度和不同類型升高。隨訪中HBsAg、抗HBe及抗HBc3項(xiàng)陽性(即“小三陽。中發(fā)現(xiàn)AFP穩(wěn)定上升型的11例(15.5%)均發(fā)展為肝癌；HBsAg、HBeAg及抗HBc3項(xiàng)陽性即“大三陽”屮發(fā)現(xiàn)AFP穩(wěn)定上升型的3例(4.8%)發(fā)展為肝癌；HBsAg、抗HBc2項(xiàng)陽性組中1例AFP穩(wěn)定上升型發(fā)展為肝癌。一過性升高和一直未升高型均未岀現(xiàn)肝癌。結(jié)論：慢性乙型肝炎小三陽感染模式動(dòng)態(tài)監(jiān)測(cè)AFP變化，對(duì)早期發(fā)現(xiàn)肝癌有重要價(jià)值。【關(guān)鍵詞】慢性乙型肝炎；AFP；肝癌ClinicalSigni
3、ficanceofDynamicObservationonSerumAFPinPatientswithChronicHepatitisBVirusAbstract：ObjectiveMonitoringdynamiclevelofserumAFPandtheirmarkerofliverfunction,todiscusstherelationshipbetweenHBVinfectionmodesandAFPchangelevelandliverfunctioninpatientswithchronichepatitisBvir
4、us,andfindthediagnosticvalueaboutprimaryhepatocellularcarcinoma.MethodsHBVinfectionmodesaredetectedbyELISAandAFPbyRIAandALT,AST,GGT,ALPbybiochemicalassaysimultaneityin189patientswithchronichepatitisBvirus.Btypeultrasonicandcomputerizedtomography(CT)wereconductedonthos
5、ewhoseAFPrisewasfoundforthefirsttimesoastoexcludelivercancer,andthentheyweretestedonhepaticfunctionandretestedonAFPandBtypeultrasoniceverytwomonthsandwerefollowedupsuccessivelyuptotwoandfiveyears.ResultsOfthe189hepatitisBvirusinfectionchildrenpatients,146riseddissimil
6、arlyindegreeandtypeaboutAFPlevel.Accordingtothefollowup,11caseswhoseAFPlevelkeptrisingsteadilywithHBsAg>antiHBeandantiHBcpositivemodelsand3casewhosewhoseAFPlevelkeptrisingsteadilywithHBsAg>HBeAgandantiHBcpositivemodelsallbecameprimaryhepatocellularcarcinoma.ButNoliver
7、cancerwasfoundamongthosewhoseAFPlevelrisedephemerallyandwhoseAFPlevelneverrised.ConclusionItisvaluableforchronichepatitisBviruspatientswithHBsAg>antiHBeandantiHBcpositivemodelstodynamiciallyobserveonitsAFPlevel,theymayfindprimaryhepatocellularcarcinomaearlier.Keywords
8、：ChronichepatitisBvirus;AFP;Hepatocellularcarcinoma甲胎蛋口(AFP)主要是由胚胎肝細(xì)胞、卵黃囊和胃腸上皮細(xì)胞產(chǎn)生的一種特殊球蛋白。健康成年人血清AFP水平小于20ng/ml,1964年Tatari
