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1、萬(wàn)方數(shù)據(jù)·76史堡監(jiān)鏖匡垣鍪盍(皇±遂2絲!蘭生!壁旦筮壘鲞筮墊魍堡塹塾!墾墮查!i!塾璺(里!塑匭!型壅i堅(jiān)):堡叢墼!!:墊!蘭,!生:魚(yú),№:墊化療聯(lián)合DC.CIK細(xì)胞治療對(duì)胰腺癌患者免疫功能的影響劉愛(ài)華【摘要】目的探討DC.CIK細(xì)胞免疫治療對(duì)化療后胰腺癌患者免疫功能的影響。方法對(duì)50例經(jīng)病理確診的胰腺癌患者依據(jù)治療方式分為兩組:化療聯(lián)合自身DC.CIK細(xì)胞治療25例患者作為聯(lián)合治療組,同期單純化療25例患者作為對(duì)照組。分別于治療前、治療后相同時(shí)間點(diǎn)取外周血,采用流式細(xì)胞儀檢測(cè)T細(xì)胞亞群及CIM+CD25+C
2、Dl27“調(diào)節(jié)性T細(xì)胞(Treg)的變化;ELISA方法檢測(cè)IFNl及IL-4水平的變化。結(jié)果聯(lián)合治療組患者治療后外周血CD3+、CD4+、CD3+CD56+T細(xì)胞百分率上升,CD4+/CD8+值上調(diào),CD8+T細(xì)胞百分率下降(P<0.05或P<0.01);CIM+CD25+CDl27”Treg下降(P<0.01);n1細(xì)胞因子IFN.’水平較治療前升高,而Th2細(xì)胞因子I“水平降低(P<0.01)。對(duì)照組單純化療后CD3+、CIM+、CD8+細(xì)胞百分率下降(P<0.05或P<0.01);CIM+CD25+CDl27
3、”Treg下降(P<0.01);IFN一^y和IL4水平降低(P均<0.01)。結(jié)論化療聯(lián)合DC.CIK細(xì)胞治療能提高胰腺癌患者的免疫功能,增強(qiáng)機(jī)體的抗腫瘤免疫效應(yīng),是治療胰腺癌患者的輔助手段之一?!娟P(guān)鍵詞】T淋巴細(xì)胞,調(diào)節(jié)性;細(xì)胞因子類;胰腺腫瘤;樹(shù)突狀細(xì)胞-細(xì)胞因子誘導(dǎo)的殺傷細(xì)胞InfluenceofchemotherapycombinedwithDC-CIKcellontheimmunefunctioninpatientswithpancreaticCallerUUAi—hua.Cer血越Laboratory。
4、TaianCentralHo印iml,Taian271000,ChinaEntail:liuaihua0698@12五com【Abstract】0bjectiveTostudytheeffectofdendriticceils—cytokineinducedkillercells(DC·CIK)immunotherapyafterchemotherapyonimmunityfunctionofpatientsofpancreaticcancer.Methods50patientswitllpathologically
5、confmmedpancreaticcancerwererandomlydividedinto2groups:combinedtherapygroup(25patientstreatedwithDC—CIKcelltherapyafterchemotherapy)andcontrolgroup(25patientstreatedwithchemotherapyonly).鴨elevelsofTcellsubsetsCD3+,CIM+,CD8+,CD4+CD25+CDl27l*"regulatoryTcellswere
6、detectedwithflowcytometryandtheIFN-1andIL4weredetectedwithELISAinperipheralbloodbeforeandafterthetreatment.ResultsTcellsubsetsCD3+,CD4+andCD3+CD56+。ratioofCD4+/CD8+wereincreasedafterDC.CIKcelltransfusionandtheCD8+cellsubsetsandCIM+CIY25+CDl2710-regulatoryTceils
7、weresignificantlydecreased(P<0.05orP<0.01).1helevelofIFN-1wereincreasedandthelevelofIL-4decreasedattheSanletime.Inthecontrolgroup,TcellsubsetsCD3+,CIM+,CD8+andCD4+CD25+CDl27t。"regulatoryTcellsweredecreasedaftertreatedwitIlchemotherapyonly(P<0.05orP<0。01).Thelev
8、elsofIFN一叮andIL4weredecreased(P<0.01).ConclusionsChemotherapycombinedwithDC-CIKcellimmunotherapyCanimprovetheimmunefunctionofpatientswithpancreaticcancerandenhancethebodyant