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1、胡頹子根的化學(xué)成分研究劉祥，丁驍，歐陽(yáng)明安，任青云(福建農(nóng)林大學(xué)生物農(nóng)藥與化學(xué)生物學(xué)教育部重點(diǎn)實(shí)驗(yàn)室，福州350002)摘耍：藥用梢物胡頹子為胡頹子科，胡頹子屬植物，主耍分布于長(zhǎng)江流域以南各省區(qū)。該屬植物含有揮發(fā)油、帖類、生物堿、黃？M等化學(xué)成分，藥理活性主要冇降血耕，降血脂、抗脂質(zhì)氧化、抗炎鉞痛、免疫等。基于以往的報(bào)道，對(duì)胡頹子根部化學(xué)成分的研究很少，為推動(dòng)新型藥物的利用和開(kāi)發(fā)，本文以采白泉州清源山的胡頹子根為研究對(duì)彖，運(yùn)用D101、SephadexLH-20.MCI柱色譜法、硅膠柱色譜法及半制備HPLC進(jìn)行分離純化到
2、六種分離物，經(jīng)核磁共振波譜解析，分別鑒定為：表兒茶素(1),1,4,9-三疑基-紫羅蘭醇(2),3’■甲氧基?懈皮素-3-O-P-D-1B萄糖伏(3),3'?甲氧基?懈皮素?3?O?ct?L?鼠李糖-(l->2)-p-D-葡萄糖貳(4),2?甲氧基苯酚-4-O-a-L-阿拉伯糖?(1->6)作D-半乳糖爪(5),對(duì)輕基苯甲酸丁酯(6)3,4-二甲氧基-5巽基■苯酚-l-0-a-D-阿拉伯Wf-(1^6)-p-D-匍萄糖貳(7)。關(guān)鍵詞：胡頹子；胡頹子科；胡頹子屈；化學(xué)成分；核磁共振中圖分類號(hào):R284.2Studyonc
3、hemicalconstituentsofrootsofElaeagnuspungensLIUXiang,DINGXiao,OUYANGMing-an,RENQingyun(KeyLaboratoryofBio-PesticideandChemistry?Biology,MinistryofEducation,FujianAgricultureandForestryUniversity,Fuzhou350002丿Abstract:MedicinalplantElaeagnuspungenswhichbelongstoth
4、efamilyElaeagnaceae,Elaeagnus,mainlydistributedintheprovincessouthoftheYangtzeRiver.Thegenuscontainingvolatileoil，terpenoids^alkaloids,flavonoidsandotherchemicalconstituents.Itspharmacologicalactivitiesmainlyhavehypoglycemic,hypolipidemic,antilipidoxidation,anti-
5、inflammatoryandanalgesic^immune^etc.Basedonpreviousreports,fewstudiesonchemicalconstituentsofElaeagnusrootDothefollowingworktopromotetheuseanddevelopmentofnewdrugs.ChemicalinvestigationoftheextractsofElaeagnuspungensrootwhichwerecollectedfromtheQingyuanMountainof
6、quanzhoubyusingvariouschromatographictechniquessuchasD101,SephadexLH-20columnchromatography,MCI,silicagelcolumnchromatography^andsemi-preparativeHPLC.SixcompoundswereobtainedandthenbyNMRspectralanalysiswereidentifiedasepicatechin(1),1,4,9-trihydroxy-megastima(2),
7、3-methoxy?quercetin?3?O?卩?D?glucopyranoside(3)93-methoxy?quercetin?3?O?(x?L-rhamnose?(l—>2)■卩?D-gIucopyranoside(4),2-methoxyphenol-4-O-a-L-arabinose-(1—>6)-p-D-galactoside(5),Butylparaben(6),3,4-dimethoxy-5-hydroxy-phenol-l-0-?-D-arabinose-(1^6)-p-D-glucopyranosi
8、de(7)>Keywords:Elaeagnuspungens;Elaeagnaceae;Elaeagnus;chemicalconstituents;NMR基金項(xiàng)目:教育部博上點(diǎn)學(xué)科專項(xiàng)基金(20103515110007,20093515120005)；福建省H然科學(xué)基金(2012J01088)作者簡(jiǎn)介：劉祥(19
