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1、萬方數(shù)據(jù)圈匪處型堂苤查!Q!!生!旦笠塑鲞筮!塑!!!!望塵!!!!』業(yè)嬰型!!!!r顯型!!!型!翌!!!!：!!!：塑：盥!．![20]UnoM，ShimadaK，YamamotoY，ela1．PeriductalinfiltratingtypeofintrahepaticchoIa“giocarcinoma：araremacroscopictypewithoutanyapparentmass[J]．SurgToday，2012，42(12)：1189．1194．DOI：10．1007／s00595—01
2、2-0145—5．(收稿日期：2015—10—15)靶向治療大腸癌的納米藥物及其載體進展潘剛殷佩浩+范躍祖【摘要】大腸癌是目前世界發(fā)病率第四位的惡性腫瘤，發(fā)病初期臨床表現(xiàn)不明顯，因此早期較難發(fā)現(xiàn)，診斷出時大多屬于進展期。進展期的治療多用化療、介入治療、放療等方法，其中化療在殺傷腫瘤細(xì)胞的同時，對正常機體細(xì)胞也有殺傷作用。近年來，各類新興納米靶向遞送系統(tǒng)不斷發(fā)展，由于納米粒子可靶向定位于腫瘤組織，因而其在腸道腫瘤尤其是伴有轉(zhuǎn)移的腸道腫瘤治療中的應(yīng)用越來越受到人們的重視。筆者針對目前納米藥物載體材料的類型、研究現(xiàn)
3、狀及其在大腸癌研究中的應(yīng)用做一綜述?！娟P(guān)鍵詞】納米藥物；納米載體材料；大腸癌；綜述；藥物載體；發(fā)病率基金項目：國家中醫(yī)藥管理局“十二五”中醫(yī)藥重點學(xué)科(中西醫(yī)結(jié)合臨床)；上海中醫(yī)藥大學(xué)“杏林學(xué)者”(B—X-73)；上海中醫(yī)藥大學(xué)附屬普陀醫(yī)院院級課題(2013ZDl941)AdvancesintargetingnanodrugtherapyanditscarrierofcolorectalcancerPan鉑昭，YinPeihao+，F(xiàn)anYuezu．DepartmentofGeneralSurgery，Put
4、uoHospitalAffiliatedtoShanghaiUniversityofTraditionalChineseMedicine，200062，ChinaCorrespondingauthor：HnPeihao，Email：yinpeiha01975@hotmail．com【Abstract】Colorectalcanceriscurrentlytheworld’Sfounhincidenceofmalignanttumors，theearlyclinicalmanifes—tationsarenot
5、obvious，SOtheearlydiagnosisisdifficulttofind，mostofthemareinprogress．Treatmentofadvancedstagewithchemotherapy，interventionaltherapy，radiotherapyandothermethods，inwhichchemotherapyinthekillingoftumorcellsatthe$anletime，thenormalcellsofthebodyalsohasakillinge
6、ffect．Inrecentyears，allkindsofnewnanotargetingdeliverysystemhasbeendeveloped，whichcanbetargetedtothetumortissue，SOitismoreandmoreimportantinthetreatmentofintestinaltumor，especiallywithmetastasis．Theauthorhasmadeanoverviewofthetypesofnanodrugcarriernmtefials
7、，theresearchstatusanditsapplicationintheresearchofcolorectalcancer．【Keywords】Nanomedicine；Nanocarriermaterial；Coloncancer；Review；Drugcarriers；IncidenceFundprogram：“Thetwelfthfiveyear”KeySubject(IntegratedChineseandWesternMedicineandGeneralPracticeTrainingof
8、TraditionalChineseMedicine)ofTraditionalChineseMedicineofStateAdministrationofTradi—tionalChineseMedicine；XinlinSchoolofShanghaiUniversityofTraditionalChineseMedicine(B—X-72)；PatuoHospital，ShanghaiUniv
