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1、·424·中國熱帶醫(yī)學(xué)2017年第17卷第4期ChinaTropicalMedicine，April2017，Vol.17，No.4·經(jīng)驗交流·左氧氟沙星對初治涂陽肺結(jié)核療效分析賴靜文，郭婉如廣州市番禺區(qū)慢性病防治站，廣東廣州511400摘要：目的探討采用左氧氟沙星對初治涂陽肺結(jié)核的療效。方法將2016年1月—5月在結(jié)核病防治科登記治療的120例初治涂陽肺結(jié)核患者隨機分為3組，分別以A組（左氧氟沙星組）4HRZEL/2HR，B組（強化期延長方案組）4HRZE/2HR，C組（標(biāo)準(zhǔn)方案組）2HRZE/4HR方案進行6個月抗結(jié)核治療。結(jié)
2、果3組2月末痰培養(yǎng)陰轉(zhuǎn)率分別為91.7%，77.1%，82.9%，5月末痰培養(yǎng)陰轉(zhuǎn)率分別為100.0%，91.4%，85.7%，6月末痰培養(yǎng)陰轉(zhuǎn)率分別為100.0%，94.3%，88.6%，3組間痰菌陰轉(zhuǎn)率差異無統(tǒng)計學(xué)意義（P>0.05)。3組6月末病灶明顯吸收率分別為80.6%，54.3%，45.7%，A組明顯高于B組和C組（P<0.05）。3組6月空洞閉合率分別為95.0%，75.0%，62.5%，A組高于C組（P<0.05）,但與B組比較差異無統(tǒng)計學(xué)意義（P＝0.077）。結(jié)論4HRZEL/2HR治療方案可提高初治涂陽肺結(jié)核
3、治愈率和病灶吸收率，但仍需進一步研究。關(guān)鍵詞：肺結(jié)核；初治；涂陽；標(biāo)準(zhǔn)化療方案；耐藥；左氧氟沙星中圖分類號：R521文獻標(biāo)識碼：A文章編號：1009-9727(2017)04-424-03DOI:10.13604/j.cnki.46-1064/r.2017.04.27LevofloxacinonprimarysmearpositivepulmonarytuberculosisLAIJingwen,GUOWanruPanyuDistrictCenterofChronsicDiseases,Guangzhou,Guangdong511
4、400,ChinaAbstract:ObjectiveToinvestigatethecurativeeffectofdifferentchemotherapyregimensinthetreatmentofnewlydiagnosedsmearpositivepulmonarytuberculosis.MethodsAtotalof120patientswithnewlydiagnosedsmearpositivepulmonarytuberculosiswererandomlydividedinto3groupsfromJan
5、uary2016toMay2016,groupA(levofloxacingroup)4HRZEL/2HR,groupB(extendedperiodgroup)4HRZE/2HR,groupC(standardgroup)2HRZE/4HRwith6monthsofantituberculosisscheme.ResultsThreegroupsofattheendoftwomonthssputumculturenegativeconversionratewere91.7%,77.1%,82.9%,attheendoffivem
6、onthssputumculturenegativeconversionratewere100.0%,91.4%,85.7%,attheendofsixmonthssputumculturenegativeconversionratewere100.0%,94.3%,88.6%.Therewasnosignificantdifferencebetweenthethreegroupsinsputumnegativeconversionrate（P>0.05).Threegroupsattheendofsixmonths,theabs
7、orptionrateoflesionswas80.6%,54.3%,45.7%,groupAwassignificantlyhigherthanthatofgroupBandgroupC（P<0.05）.Theclosurerateofthethreegroupswas95.0%,75.0%,62.5%attheendofsixmonths,groupAwashigherthangroupC（P<0.05）.However,therewasnosignificantdifferencebetweenthegroupBandgro
8、upA(P＝0.077）.Conclusion4HRZEL/2HRtreatmentcanimprovethecurerateandtheabsorptionrateofsmearpositivepulmonarytuberculosis,buti
