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1、167P13.08W11.03PERIPHERALNEUROPATHYORCHESTRATEDBYNONNEURAL-PHENOTYPICANDFUNCTIONALPROPERTIESOFCD8+T-LYMPHO-SPECIFICTLYMPHOCYTES.CYTESFROMTHECNSOFRATSWITHCORONAVIRUS-INDUCED~*,It.Gold,K.V.ToykaandH.-P.HartungENCEPHALOMYELITISNeurologischeUniversitiitsk
2、linik,Julius-MaximiliansUniversitiit,Wiirzburg,Germany.*InstituteofClinicalNeurosciences,UniversityofA.Hein1,H.Imrich1,S.Sopperl,S.Schwender2andR.DOmes1.Sydney,Australia.llnst,f.VirologicundImmanbiologieand2ZentrallaborderMedizinischenKlinikNeural-spe
3、cificTcellsareheldtoplayapivotalroleintheGuillain-tierUniversitatWttrzburg,GermanyBarr6syndrome,andexperimentalallergicneuritis(EAN).Here,theeffectsofintraneuralaccumulationofnonneural-specificTcellonblood-IntmcerebralinfectionofLewisfLEW)mrswiththemo
4、rinecoronavirusJH]vlnervebarrierpermeabilityandperipheralnervefunctionwereassessed.(JHMV)typicallyresultsinademyelinatingencephalomyelitisaccompaniedbyaRatovalbumin(OA)-specificTcellswereactivatedinvitroandonday0monophasic,paralyticdisease.Incontrast,
5、noclinicalsignscanheobservedinintravenouslytransferredtofemaleadultLewisrats.RatswerethengivenJHMVinfectedBrownNorway(BN)rats.InbothratstrainsCDg+T-lymphncytesintraneuralinjectionsofOAorcaseinintoleftandfighttibialnervescontributesignificantlytotheinf
6、lammatoryinfiltrateinvirus-infectedCNSlesions.respectively.Ondays3and4,selectedratsalsoreceivedintravenousPhonotypicandfunctionalpropertiesoftheseCDg+Tcellswerecllmacterisedbypurifiedimmunoglobulinfromrabbitswithmyelin-inducedEAN,flowcytometryanddeten
7、ninatinoofvims-spacificcellmediatedcytotoxicityatRapidaccumulationofct/(~TcellsandED1+macrophagesandmarkeddifferenttimespastinfection.InLEWrats.inaverage10timesmoreCDg+Tlym-increasesinblood-nervebarrierpermeabilityinOAbutnotcaseininjectedphocyteswerer
8、ecoveredfromtheCNScomparedtotheBNratpopulation.Never-theless,inbothratstrainsthemajorityofthesecellsischamcterisedbythelossofnervesfollowedtransferof2x106Tcells.5x106TceilsinduceddecreasesintheCD45RCmolecule,indicatingaprimedoractivatedstate.I
