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《冠狀病毒Coronavirusl論文-2007 O349 Molecular epidemiology, genotypes and recombination of coronavirus HKU1, a novel human coronavirus associated.pdf》由會員上傳分享，免費在線閱讀，更多相關內容在學術論文-天天文庫。
1、S7217thECCMID/25thICC,Oralpresentationsofantibioticsandhavehadasigni?cantroleinthediscoveryandcomparedwith93.7%(135/144)forDFA/culture.RVPdetectedandevelopmentofcommerciallysuccessfuldrugsofallclasses.Over75%additional26con?rmedpositivesincluding22Rhino/Entero,1NL63,ofth
2、eantibacterialnewchemicalentities(NCEs)introducedworldwideand3HKU1thatarenotroutinelytestedbyDFAorcultureandbetween1981and2002werebasedonnaturalproducts.Theunmatched4additionalFluBpositivesthatweremissedbyDFA/culture.chemicaldiversityandcomplexityofnaturalproductsisonere
3、asonforConclusion:TheID-TagRVPtestismoresensitivethanDFA/culturetheirsuccessoverthoseobtainedbypurechemicalsynthesis.Anotheranddetectsanumberofrespiratoryvirusesnotroutinelytestedfor.reasonfortheirsuperioritycanbeexplainedbythefactthattheirOverall22.5%additionalpositives
4、pecimensweredetectedthatweresynthesisevolvednaturallyinresponsetoneedsandchallengesoftheeithermissedbyDFA/cultureornottestedfor.TheID-TagRVPtestnaturalenvironmentgeneratingcompoundswhicharepre-selectedforshouldimprovetheabilityofhospitalandpublichealthlaboratoriestoactiv
5、ity.Despitethesefacts,naturalproductresearchhasrecentlygonediagnoseviralRTIsinahospitalorcommunityoutbreaksituation.throughaphaseofreducedinterest.Bigpharmaceuticalcompaniesinparticularhavedowngradedorevenstoppedthiskindofresearch.Thereasonsforthisdevelopmentmaybethatnat
6、uralproductsareoftenO349Molecularepidemiology,genotypesandrecombinationofproducedinlowquantitiesandasmixturesofsimilarcompounds,thecoronavirusHKU1,anovelhumancoronavirusassociatedrediscoveryofknowncompoundsandthechallengeofnaturalproductwithrespiratorytractinfectionsderi
7、vatisationusingclassicalchemicalmeans.P.C.Y.Woo,S.K.P.Lau,C.C.Y.Yip,Y.Huang,H.W.Tsoi,R.W.S.Poon,ThepastfewyearshavewitnessedmajordevelopmentsintheuseofB.H.L.Wong,K.H.Chan,K.Y.Yuen(HongKong,HK)innovativenaturalproductrelatedtechnologies,suchasfermentationoptimisation,sepa
8、ration,structureelucidationanddereplicationallowingObjectives:Recently,wedescribedthediscoveryofanovelg
