陰性淋巴結數目對胃癌手術患者預后的影響.pdf

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1、·3632·現代預防醫(yī)學2014年第41卷第19期ModemPreventiveMedicine，2014，Vo1．41，NO．19·臨床與預防·陰性淋巴結數目對胃癌手術患者預后的影響易偉，錢洪軍，陳帆解放軍第九四醫(yī)院普外科，江西南昌330002摘要：目的探討陰性淋巴結數目對胃癌手術患者預后的影響。方法回顧性分析2006年1月一2009年9月有完整隨訪資料的203例胃癌手術患者的臨床資料，分別對影響腫瘤復發(fā)及術后生存時間的預后因素進行單因素及多因素分析。結果203例胃癌手術患者的總體復發(fā)率為34．98％，總體3年生存率為71．92％。單因素分析顯示更少的陰性淋巴結數目(<10枚)是影

2、響胃癌患者術后復發(fā)及生存時間的顯著危險因素(P

3、impactofthenumberofnegativelymphnodesingastriccancerpatientsaftercurativegastrectomyYIWei，QIANHong~Ha，CHENFanDepartmentofGeneralSurgery,the94MilitaryHospitaloftheChinesePeopleLiberationArmy,Nanchang,Jiangxi330002，ChinaAbstract：ObjectiveToinvestigatetheprognosticimpactofthenumberofnegativelymphn

4、odesingastriccanceraftercurativegastreetomy．MethodsThisstudyinvolved203patientswithgastriccancer，whounderwentcurativegastrectomywithcompletefollow-updatafromJanuary2006toSeptember2009．Factorswhichinfluencedtumorrecurrenceandoverallsurvivaltimewereevaluatedbyunivariateandmultivariateanalysis．Res

5、ultsTherecurrencerateof203patientswithgastriccancerwas34．98％，andthe3-yearoveralsurvivalratewas71．92％．Onunivariateanalysis，thefewernegativelymphnodes(<10)hadastatisticallysignificantnegativeimpactontumorrecurenceandoverallsurvivaltime(尸0．01)．Multivariateanalysisshowedthattumorsize，tumordiferenti

6、ation，depthofinvasion，thenumberofpositivelymphnodes，andthenumberofnegativelymphnodeswereindependentpredictorsoftumorrecurrenceandoverallsurvivaltime．Stratifiedanalysisrevealedthatthefewernegativelymphnodes(<1o)hadastatisticallysignificantnegativeimpactonoverallsurvivaltime(尸≮0．01)ingastriccance

7、rpatientswithstageIII．ConclusionInsuficientnumberofnegativelymphnodesisanindependentriskfactoraffectingtheprognosisofpatientswithgastriccancerundergoingcurativegastrectomy．Morelymphnodesshouldbereseetedtoinsuresuficientnumberofneg